PMID- 24991089 OWN - NLM STAT- MEDLINE DCOM- 20150212 LR - 20211021 IS - 1466-1861 (Electronic) IS - 0962-9351 (Print) IS - 0962-9351 (Linking) VI - 2014 DP - 2014 TI - Inflammatory markers and obstructive sleep apnea in obese children: the NANOS study. PG - 605280 LID - 10.1155/2014/605280 [doi] LID - 605280 AB - INTRODUCTION: Obesity and obstructive sleep apnea syndrome (OSA) are common coexisting conditions associated with a chronic low-grade inflammatory state underlying some of the cognitive, metabolic, and cardiovascular morbidities. AIM: To examine the levels of inflammatory markers in obese community-dwelling children with OSA, as compared to no-OSA, and their association with clinical and polysomnographic (PSG) variables. Methods. In this cross-sectional, prospective multicenter study, healthy obese Spanish children (ages 4-15 years) were randomly selected and underwent nocturnal PSG followed by a morning fasting blood draw. Plasma samples were assayed for multiple inflammatory markers. RESULTS: 204 children were enrolled in the study; 75 had OSA, defined by an obstructive respiratory disturbance index (RDI) of 3 events/hour total sleep time (TST). BMI, gender, and age were similar in OSA and no-OSA children. Monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) levels were significantly higher in OSA children, with interleukin-6 concentrations being higher in moderate-severe OSA (i.e., AHI > 5/hrTST; P < 0.01), while MCP-1 levels were associated with more prolonged nocturnal hypercapnia (P < 0.001). CONCLUSION: IL-6, MCP-1, and PAI-1 are altered in the context of OSA among community-based obese children further reinforcing the proinflammatory effects of sleep disorders such as OSA. This trial is registered with ClinicalTrials.gov NCT01322763. FAU - Gileles-Hillel, Alex AU - Gileles-Hillel A AD - Section of Sleep Medicine, Department of Pediatrics, Comer Children's Hospital, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, 5721 S. Maryland Avenue, Chicago, IL 60637, USA. FAU - Alonso-Alvarez, Maria Luz AU - Alonso-Alvarez ML AD - Sleep Unit, Instituto Carlos III.CIBERES, Spain ; CIBER of Respiratory Diseases, Instituto Carlos III.CIBERES, Spain ; Hospital Universitario de Burgos (HUBU), Burgos, Spain. FAU - Kheirandish-Gozal, Leila AU - Kheirandish-Gozal L AD - Section of Sleep Medicine, Department of Pediatrics, Comer Children's Hospital, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, 5721 S. Maryland Avenue, Chicago, IL 60637, USA. FAU - Peris, Eduard AU - Peris E AD - Section of Sleep Medicine, Department of Pediatrics, Comer Children's Hospital, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, 5721 S. Maryland Avenue, Chicago, IL 60637, USA. FAU - Cordero-Guevara, Jose Aurelio AU - Cordero-Guevara JA AD - Sleep Unit, Instituto Carlos III.CIBERES, Spain ; CIBER of Respiratory Diseases, Instituto Carlos III.CIBERES, Spain ; Hospital Universitario de Burgos (HUBU), Burgos, Spain. FAU - Teran-Santos, Joaquin AU - Teran-Santos J AD - Sleep Unit, Instituto Carlos III.CIBERES, Spain ; CIBER of Respiratory Diseases, Instituto Carlos III.CIBERES, Spain ; Hospital Universitario de Burgos (HUBU), Burgos, Spain. FAU - Martinez, Monica Gonzalez AU - Martinez MG AD - Sleep Unit, Instituto Carlos III.CIBERES, Spain ; Hospital Universitario Valdecilla, Santander, Spain. FAU - Jurado-Luque, Maria Jose AU - Jurado-Luque MJ AD - Sleep Unit, Instituto Carlos III.CIBERES, Spain ; CIBER of Respiratory Diseases, Instituto Carlos III.CIBERES, Spain ; Hospital Val d'Hebron, Barcelona, Spain. FAU - Corral-Penafiel, Jaime AU - Corral-Penafiel J AD - Sleep Unit, Instituto Carlos III.CIBERES, Spain ; CIBER of Respiratory Diseases, Instituto Carlos III.CIBERES, Spain ; Hospital San Pedro de Alcantara, Caceres, Spain. FAU - Duran-Cantolla, Joaquin AU - Duran-Cantolla J AD - Sleep Unit, Instituto Carlos III.CIBERES, Spain ; CIBER of Respiratory Diseases, Instituto Carlos III.CIBERES, Spain ; Servicio de Investigacion, Hospital Universitario Araba (BioAraba), Universidad del Pais Vasco (UPV/EHU), Vitoria, Spain. FAU - Gozal, David AU - Gozal D AD - Section of Sleep Medicine, Department of Pediatrics, Comer Children's Hospital, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, 5721 S. Maryland Avenue, Chicago, IL 60637, USA. LA - eng SI - ClinicalTrials.gov/NCT01322763 GR - R01 HL065270/HL/NHLBI NIH HHS/United States GR - UL1 TR000430/TR/NCATS NIH HHS/United States GR - HL-65270/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20140601 PL - United States TA - Mediators Inflamm JT - Mediators of inflammation JID - 9209001 RN - 0 (Chemokine CCL2) RN - 0 (Interleukin-6) RN - 0 (Plasminogen Activator Inhibitor 1) RN - 0 (SERPINE1 protein, human) SB - IM MH - Adolescent MH - Animals MH - Chemokine CCL2/blood MH - Child MH - Child, Preschool MH - Cross-Sectional Studies MH - Female MH - Humans MH - Interleukin-6/blood MH - Male MH - Obesity/*blood/*physiopathology MH - Plasminogen Activator Inhibitor 1/blood MH - Prospective Studies MH - Sleep Apnea, Obstructive/*blood/*physiopathology PMC - PMC4058796 EDAT- 2014/07/06 06:00 MHDA- 2015/02/13 06:00 PMCR- 2014/06/01 CRDT- 2014/07/04 06:00 PHST- 2014/03/13 00:00 [received] PHST- 2014/04/17 00:00 [revised] PHST- 2014/05/01 00:00 [accepted] PHST- 2014/07/04 06:00 [entrez] PHST- 2014/07/06 06:00 [pubmed] PHST- 2015/02/13 06:00 [medline] PHST- 2014/06/01 00:00 [pmc-release] AID - 10.1155/2014/605280 [doi] PST - ppublish SO - Mediators Inflamm. 2014;2014:605280. doi: 10.1155/2014/605280. Epub 2014 Jun 1.