PMID- 24992303
OWN - NLM
STAT- MEDLINE
DCOM- 20150508
LR  - 20211021
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Print)
IS  - 0013-936X (Linking)
VI  - 48
IP  - 15
DP  - 2014
TI  - Measurements of selected brominated flame retardants in nursing women: 
      implications for human exposure.
PG  - 8873-80
LID - 10.1021/es5016839 [doi]
AB  - We have examined several emerging brominated flame retardants (BFRs) including 
      2-ethyl-1-hexyl-2,3,4,5-tetrabromobenzoate (TBB), bis(2-ethylhexyl) 
      tetrabromophthalate (TBPH), 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), 
      4,5,6,7-tetrabromo-1,1,3-trimethyl-3-(2,3,4,5-tetrabromophenyl)-indane (OBIND), 
      and decabromodiphenyl ethane (DBDPE) in paired human maternal serum (n = 102) and 
      breast milk (n = 105) collected in 2008-2009 in the Sherbrooke region in Canada. 
      Three legacy BFRs were also included in the study for comparison: 
      decabromobiphenyl (BB-209), 2,2',4,4',5,5'-hexabromobiphenyl (BB-153), and 
      2,2',4,4',5,5'-hexabromodiphenyl ethers (BDE-153). TBB, BB-153, and BDE-153 had 
      detection frequencies greater than 55% in both serum and milk samples. Their 
      lipid weight (lw) adjusted median concentrations (ng g(-1) lw) in serum and milk 
      were 1.6 and 0.41 for TBB, 0.48 and 0.31 for BB-153, and 1.5 and 4.4 for BDE-153, 
      respectively. The detection frequencies for the other BFRs measured in serum and 
      milk were 16.7% and 32.4% for TBPH, 3.9% and 0.0% for BTBPE, 2.0% and 0.0% for 
      BB-209, 9.8% and 1.0% for OBIND, and 5.9% and 8.6% for DBDPE. The ratio of TBB 
      over the sum of TBB and TBPH (fTBB) in serum (0.23) was lower than that in milk 
      (0.46), indicating TBB has a larger tendency than TBPH to be redistributed from 
      blood to milk. Overall, these data confirm the presence of non-PBDE BFRs in 
      humans, and the need to better understand their sources, routes of exposure, and 
      potential human health effects.
FAU - Zhou, Simon Ningsun
AU  - Zhou SN
AD  - Exposure and Biomonitoring Division, Health Canada , Ottawa, Ontario K1A 0K9, 
      Canada.
FAU - Buchar, Angelina
AU  - Buchar A
FAU - Siddique, Shabana
AU  - Siddique S
FAU - Takser, Larissa
AU  - Takser L
FAU - Abdelouahab, Nadia
AU  - Abdelouahab N
FAU - Zhu, Jiping
AU  - Zhu J
LA  - eng
GR  - MOP-84551/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140717
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Environmental Pollutants)
RN  - 0 (Flame Retardants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Brominated)
SB  - IM
MH  - Adult
MH  - Breast Feeding
MH  - Canada
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*analysis/chemistry/pharmacokinetics
MH  - Female
MH  - Flame Retardants/*analysis/pharmacokinetics
MH  - Halogenated Diphenyl Ethers/*analysis/chemistry/pharmacokinetics
MH  - Humans
MH  - Hydrocarbons, Brominated/*analysis/chemistry/pharmacokinetics
MH  - *Maternal Exposure
MH  - Milk, Human/*chemistry
MH  - Molecular Structure
MH  - Tissue Distribution
PMC - PMC4124063
EDAT- 2014/07/06 06:00
MHDA- 2015/05/09 06:00
PMCR- 2014/08/06
CRDT- 2014/07/04 06:00
PHST- 2014/07/04 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/05/09 06:00 [medline]
PHST- 2014/08/06 00:00 [pmc-release]
AID - 10.1021/es5016839 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2014;48(15):8873-80. doi: 10.1021/es5016839. Epub 2014 Jul 
      17.