PMID- 24993299
OWN - NLM
STAT- MEDLINE
DCOM- 20150413
LR  - 20191210
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 578
DP  - 2014 Aug 22
TI  - Further evidence for the role of interferon-gamma on anxiety- and depressive-like 
      behaviors: involvement of hippocampal neurogenesis and NGF production.
PG  - 100-5
LID - S0304-3940(14)00520-5 [pii]
LID - 10.1016/j.neulet.2014.06.039 [doi]
AB  - A series of evidence suggests that interferon-gamma (IFN-gamma) plays an important 
      role in central nervous system (CNS) functions. However, previous studies have 
      obtained inconsistent results regarding the role of IFN-gamma in modulating 
      emotion-related behaviors. The present study aimed to evaluate the behavioral 
      profile of IFN-gamma knockout (K.O.) mice in models of anxiety and depression. Male 
      C57Bl6 wild type (WT) or IFN-gamma K.O. mice were submitted to the following tests: 
      contextual fear conditioning (CFC), elevated plus maze (EPM), open field (OF) and 
      forced swimming test (FST). To explore the possible neurobiological mechanisms 
      involved, we also assessed hippocampal neurogenesis by means of hippocampal 
      doublecortin expression, and the levels of brain-derived neurothophic factor 
      (BDNF) and nerve growth factor (NGF) in the hippocampus and prefrontal cortex. 
      Our results suggested that IFN-gamma K.O. mice exhibited an anxiogenic profile in 
      CFC, EPM and OF tests. In FST, the K.O. group spent more time immobile than the 
      WT group. The number of doublecortin positive cells was reduced in the dentate 
      gyrus, and the expression of NGF was down regulated in the prefrontal cortex of 
      IFN-gamma K.O. mice. Our results suggest that IFN-gamma is involved in CNS plasticity, 
      contributing to the modulation of anxiety and depressive states.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Campos, Alline C
AU  - Campos AC
AD  - Group of Neuroimmunology, Laboratory of Immunopharmacology, Institute of 
      Biological Sciences and School of Medicine, Federal University of Minas Gerais, 
      Belo Horizonte, Brazil; Infectious Diseases and Tropical Medicine Graduate 
      Program, Medical School, Federal University of Minas Gerais, Belo Horizonte, MG, 
      Brazil. Electronic address: allinecampos@usp.br.
FAU - Vaz, Gabriela N
AU  - Vaz GN
AD  - Group of Neuroimmunology, Laboratory of Immunopharmacology, Institute of 
      Biological Sciences and School of Medicine, Federal University of Minas Gerais, 
      Belo Horizonte, Brazil; Infectious Diseases and Tropical Medicine Graduate 
      Program, Medical School, Federal University of Minas Gerais, Belo Horizonte, MG, 
      Brazil.
FAU - Saito, Viviane M
AU  - Saito VM
AD  - Group of Neuroimmunology, Laboratory of Immunopharmacology, Institute of 
      Biological Sciences and School of Medicine, Federal University of Minas Gerais, 
      Belo Horizonte, Brazil.
FAU - Teixeira, Antonio L
AU  - Teixeira AL
AD  - Group of Neuroimmunology, Laboratory of Immunopharmacology, Institute of 
      Biological Sciences and School of Medicine, Federal University of Minas Gerais, 
      Belo Horizonte, Brazil; Infectious Diseases and Tropical Medicine Graduate 
      Program, Medical School, Federal University of Minas Gerais, Belo Horizonte, MG, 
      Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140701
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Anxiety/*metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Conditioning, Psychological
MH  - Depression/*metabolism
MH  - Fear/physiology
MH  - Hippocampus/*metabolism
MH  - Interferon-gamma/genetics/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Nerve Growth Factor/*metabolism
MH  - *Neurogenesis
MH  - Prefrontal Cortex/metabolism
OTO - NOTNLM
OT  - Anxiety
OT  - Depression
OT  - Hippocampal neurogenesis
OT  - Interferon-gamma
OT  - Nerve growth factor
OT  - Prefrontal cortex
EDAT- 2014/07/06 06:00
MHDA- 2015/04/14 06:00
CRDT- 2014/07/05 06:00
PHST- 2014/02/04 00:00 [received]
PHST- 2014/06/06 00:00 [revised]
PHST- 2014/06/23 00:00 [accepted]
PHST- 2014/07/05 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/04/14 06:00 [medline]
AID - S0304-3940(14)00520-5 [pii]
AID - 10.1016/j.neulet.2014.06.039 [doi]
PST - ppublish
SO  - Neurosci Lett. 2014 Aug 22;578:100-5. doi: 10.1016/j.neulet.2014.06.039. Epub 
      2014 Jul 1.