PMID- 24993315
OWN - NLM
STAT- MEDLINE
DCOM- 20141112
LR  - 20151119
IS  - 1532-8392 (Electronic)
IS  - 0046-8177 (Linking)
VI  - 45
IP  - 9
DP  - 2014 Sep
TI  - The utility of p63, p40, and GATA-binding protein 3 immunohistochemistry in 
      diagnosing micropapillary urothelial carcinoma.
PG  - 1824-9
LID - S0046-8177(14)00187-7 [pii]
LID - 10.1016/j.humpath.2014.04.015 [doi]
AB  - Micropapillary urothelial carcinoma (MPUC) is an uncommon variant of urothelial 
      carcinoma (UC) with an aggressive clinical course. There have been limited 
      studies on the UC markers GATA-binding protein 3 (GATA3), p63, and p40 in MPUC. 
      Our study investigated the immunoreactivity of these 3 markers in MPUC compared 
      with conventional UC of different grades and stages. Immunohistochemistry was 
      performed on 62 cases of high-grade urothelial carcinoma (HGUC), 16 low-grade 
      urothelial carcinoma (LGUC), and 20 MPUC. p63 expression was strong and diffuse 
      in all LGUC, significantly decreased in high stage and HGUC, and virtually absent 
      in MPUC. p40 expression was decreased in HGUC and markedly decreased in MPUC 
      relative to LGUC. These results suggest that loss of p63 expression in a UC 
      appears to be associated with adverse features--including cases with 
      micropapillary differentiation. Decreased GATA3 expression was seen frequently in 
      high-grade and high-pathologic stage (>/=pT2) tumors but was retained in MPUC 
      cases. The findings of retained GATA3 expression in MPUC, which often shows a 
      loss of expression of other urothelial markers such as p63, may be helpful for 
      determining the origin of micropapillary carcinoma of unknown primary. Compared 
      with the traditional markers p63 and p40, GATA3 is the most sensitive marker of 
      conventional UC and MPUC.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Lin, Xiaoqi
AU  - Lin X
AD  - Department of Pathology, Northwestern Memorial Hospital, Northwestern University 
      Feinberg School of Medicine, Chicago, IL 60611.
FAU - Zhu, Bing
AU  - Zhu B
AD  - Department of Pathology, Northwestern Memorial Hospital, Northwestern University 
      Feinberg School of Medicine, Chicago, IL 60611.
FAU - Villa, Celina
AU  - Villa C
AD  - Department of Pathology, Northwestern Memorial Hospital, Northwestern University 
      Feinberg School of Medicine, Chicago, IL 60611.
FAU - Zhong, Minghao
AU  - Zhong M
AD  - Department of Pathology, Westchester Medical Center, Valhalla, NY 10595.
FAU - Kundu, Shilajit
AU  - Kundu S
AD  - Department of Urology, Northwestern Memorial Hospital, Northwestern University 
      Feinberg School of Medicine, Chicago, IL 60611.
FAU - Rohan, Stephen M
AU  - Rohan SM
AD  - Department of Pathology, Northwestern Memorial Hospital, Northwestern University 
      Feinberg School of Medicine, Chicago, IL 60611.
FAU - Yang, Ximing J
AU  - Yang XJ
AD  - Department of Pathology, Northwestern Memorial Hospital, Northwestern University 
      Feinberg School of Medicine, Chicago, IL 60611. Electronic address: 
      xyang@northwestern.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140508
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CKAP4 protein, human)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (GATA3 protein, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (TP63 protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*metabolism
MH  - Carcinoma, Papillary/*metabolism/pathology
MH  - Carcinoma, Transitional Cell/*metabolism/pathology
MH  - Cohort Studies
MH  - Female
MH  - GATA3 Transcription Factor/metabolism
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Membrane Proteins/metabolism
MH  - Middle Aged
MH  - Transcription Factors/metabolism
MH  - Tumor Suppressor Proteins/metabolism
MH  - Urologic Neoplasms/*metabolism/pathology
MH  - Urothelium/pathology
OTO - NOTNLM
OT  - GATA3
OT  - Micropapillary
OT  - Urothelial carcinoma
OT  - p40
OT  - p63
EDAT- 2014/07/06 06:00
MHDA- 2014/11/13 06:00
CRDT- 2014/07/05 06:00
PHST- 2014/01/23 00:00 [received]
PHST- 2014/04/13 00:00 [revised]
PHST- 2014/04/16 00:00 [accepted]
PHST- 2014/07/05 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2014/11/13 06:00 [medline]
AID - S0046-8177(14)00187-7 [pii]
AID - 10.1016/j.humpath.2014.04.015 [doi]
PST - ppublish
SO  - Hum Pathol. 2014 Sep;45(9):1824-9. doi: 10.1016/j.humpath.2014.04.015. Epub 2014 
      May 8.