PMID- 24993330
OWN - NLM
STAT- MEDLINE
DCOM- 20150528
LR  - 20181202
IS  - 1879-0887 (Electronic)
IS  - 0167-8140 (Linking)
VI  - 112
IP  - 1
DP  - 2014 Jul
TI  - The importance of actual tumor growth rate on disease free survival and overall 
      survival in laryngeal squamous cell carcinoma.
PG  - 119-24
LID - S0167-8140(14)00227-8 [pii]
LID - 10.1016/j.radonc.2014.06.004 [doi]
AB  - BACKGROUND AND PURPOSE: Evaluation of the variation in tumor growth rate and the 
      influence of tumor growth rate on disease free survival (DFS) and overall 
      survival (OS) in laryngeal squamous cell carcinoma (LSCC). MATERIAL AND METHODS: 
      We delineated tumor volume on a diagnostic and planning CT scan in 131 patients 
      with laryngeal squamous cell carcinoma and calculated the tumor growth rate. 
      Primary endpoint was DFS. Follow up data were collected retrospectively. RESULTS: 
      A large variation in tumor growth rate was seen. When dichotomized with a cut-off 
      point of -0.3 ln(cc/day), we found a significant association between high growth 
      rate and worse DFS (p = 0.008) and OS (p = 0.013). After stepwise adjustment for 
      potential confounders (age, differentiation and tumor volume) this significant 
      association persisted. However, after adjustment of N-stage association 
      disappeared. Exploratory analyses suggested a strong association between N-stage 
      and tumor growth rate. CONCLUSIONS: In laryngeal squamous cell carcinoma, there 
      is a large variation in tumor growth rate. This tumor growth rate seems to be an 
      important factor in disease free survival and OS. This tumor growth rate is 
      independent of age, differentiation and tumor volume associated with DFS, but 
      N-stage seems to be a more important risk factor.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - van Bockel, Liselotte W
AU  - van Bockel LW
AD  - University Medical Centre Utrecht, Department of Radiation Oncology, The 
      Netherlands. Electronic address: l.w.vanbockel@umcutrecht.nl.
FAU - Verduijn, Gerda M
AU  - Verduijn GM
AD  - Erasmus Medical Centre, Department of Radiation Oncology, Rotterdam, The 
      Netherlands. Electronic address: g.verduijn@erasmusmc.nl.
FAU - Monninkhof, Evelyn M
AU  - Monninkhof EM
AD  - University Medical Centre Utrecht, Julius Center for Health Sciences and Primary 
      Care, The Netherlands. Electronic address: e.monninkhof@umcutrecht.nl.
FAU - Pameijer, Frank A
AU  - Pameijer FA
AD  - University Medical Centre Utrecht, Department of Radiology, The Netherlands. 
      Electronic address: f.a.pameijer@umcutrecht.nl.
FAU - Terhaard, Chris H J
AU  - Terhaard CH
AD  - University Medical Centre Utrecht, Department of Radiation Oncology, The 
      Netherlands. Electronic address: c.h.j.terhaard@umcutrecht.nl.
LA  - eng
PT  - Journal Article
DEP - 20140630
PL  - Ireland
TA  - Radiother Oncol
JT  - Radiotherapy and oncology : journal of the European Society for Therapeutic 
      Radiology and Oncology
JID - 8407192
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/mortality/*pathology/*radiotherapy
MH  - Disease Progression
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*diagnostic imaging/mortality/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Tomography, X-Ray Computed
MH  - *Tumor Burden
OTO - NOTNLM
OT  - DFS
OT  - Doubling time
OT  - Growth rate
OT  - Laryngeal carcinoma
OT  - OS
OT  - Outcome
EDAT- 2014/07/06 06:00
MHDA- 2015/05/29 06:00
CRDT- 2014/07/05 06:00
PHST- 2012/07/11 00:00 [received]
PHST- 2014/05/30 00:00 [revised]
PHST- 2014/06/02 00:00 [accepted]
PHST- 2014/07/05 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/05/29 06:00 [medline]
AID - S0167-8140(14)00227-8 [pii]
AID - 10.1016/j.radonc.2014.06.004 [doi]
PST - ppublish
SO  - Radiother Oncol. 2014 Jul;112(1):119-24. doi: 10.1016/j.radonc.2014.06.004. Epub 
      2014 Jun 30.