PMID- 24993387
OWN - NLM
STAT- MEDLINE
DCOM- 20150707
LR  - 20210820
IS  - 1423-0208 (Electronic)
IS  - 0251-5350 (Linking)
VI  - 43
IP  - 1
DP  - 2014
TI  - The Hellenic Longitudinal Investigation of Aging and Diet (HELIAD): rationale, 
      study design, and cohort description.
PG  - 9-14
LID - 10.1159/000362723 [doi]
AB  - BACKGROUND: Accumulating epidemiological evidence from several populations 
      supports the important role of the Mediterranean-type diet (MeDi) in reducing the 
      risk for age-related diseases such as Alzheimer's disease (AD). However, the 
      relevant literature is clearly deficient for most Mediterranean countries that 
      more closely adhere to the originally described MeDi. Greece resides in the 
      Mediterranean basin, and older generations traditionally adhere to a MeDi. 
      METHODS: We here present the design and the preliminary baseline characteristics 
      of the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD). The HELIAD 
      is a population-based, multidisciplinary, collaborative study designed to 
      estimate the prevalence and incidence of AD, other dementias, mild cognitive 
      impairment, and other neuropsychiatric conditions of aging in the Greek 
      population and to investigate associations between nutrition and cognitive 
      dysfunction/age-related neuropsychiatric diseases in this Mediterranean 
      population. The study also ascertains several demographic, medical, social, 
      environmental, clinical, nutritional, and neuropsychological determinants and 
      lifestyle activities. RESULTS: In total, 1,050 participants of a random sample 
      have already completed the initial evaluation. The subjects were, on average, 
      73.4 (SD = 6.0) years old, 60% of the sample were female, and most of the 
      participants were poorly educated with an average of 5.41 (SD = 3.5) years of 
      education. The performance on the neuropsychological tests was equivalent to the 
      average scores of previous normative Greek samples. More than one third of the 
      population under investigation was considered to be at high risk for 
      malnutrition. CONCLUSIONS: The HELIAD may provide important data for expanding 
      our knowledge regarding the prevalence, incidence, and risk factors of AD and 
      several other neuropsychiatric diseases in the Mediterranean region.
CI  - (c) 2014 S. Karger AG, Basel.
FAU - Dardiotis, Efthimios
AU  - Dardiotis E
AD  - Department of Neurology, Faculty of Medicine, University of Thessaly, Larissa, 
      Greece.
FAU - Kosmidis, Mary H
AU  - Kosmidis MH
FAU - Yannakoulia, Mary
AU  - Yannakoulia M
FAU - Hadjigeorgiou, Georgios M
AU  - Hadjigeorgiou GM
FAU - Scarmeas, Nikolaos
AU  - Scarmeas N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140702
PL  - Switzerland
TA  - Neuroepidemiology
JT  - Neuroepidemiology
JID - 8218700
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aging
MH  - Alzheimer Disease/epidemiology
MH  - *Diet, Mediterranean
MH  - Female
MH  - Greece/epidemiology
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Neuropsychological Tests
MH  - *Research Design
MH  - Risk Factors
EDAT- 2014/07/06 06:00
MHDA- 2015/07/08 06:00
CRDT- 2014/07/05 06:00
PHST- 2013/12/03 00:00 [received]
PHST- 2014/04/08 00:00 [accepted]
PHST- 2014/07/05 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/07/08 06:00 [medline]
AID - 000362723 [pii]
AID - 10.1159/000362723 [doi]
PST - ppublish
SO  - Neuroepidemiology. 2014;43(1):9-14. doi: 10.1159/000362723. Epub 2014 Jul 2.