PMID- 24993632
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20240229
IS  - 1689-0035 (Electronic)
IS  - 0065-1400 (Linking)
VI  - 74
IP  - 2
DP  - 2014
TI  - Gender differences in the neurochemical response of trigeminal ganglion neurons 
      to peripheral inflammation in mice.
PG  - 227-32
LID - 1988 [pii]
LID - 10.55782/ane-2014-1988 [doi]
AB  - It is well established that the majority of headache and other trigeminal 
      nerve-associated disorders have higher prevalence in females than in males. 
      However, the pathogenesis of many chronic trigeminal pain conditions, such as 
      trigeminal neuralgia, migraine and temporo-mandibular disorders, is still not 
      known. One of the proposed mechanisms involve calcitonin gene-related peptide 
      (CGRP), which is considered the most important neuropeptide in the trigeminal 
      system. In various animal models of trigeminal nerve-associated disorders 
      concentration of CGRP has been shown to be increased in trigeminal ganglia (TG). 
      Moreover, intraganglionic release of CGRP has been shown to modulate neuronal 
      transmission of pain signals. In most of these models, pathological changes in 
      the trigeminal system are accompanied by inflammation within peripheral endings 
      of TG neurons. The aim of the present study was to investigate the relation 
      between gender and neurochemical changes in trigeminal ganglia evoked by 
      peripheral inflammation, induced by Complete Freund Adjuvant (CFA) 
      administration. Our studies show significant increase in CGRP expression in 
      female mice, comparing to male mice. Furthermore, we demonstrate, that activation 
      of trigeminal nociceptors by peripheral inflammation causes significant increase 
      in expression of IL-1B, IL-6, TNF and BDNF in male mice, comparing to female 
      mice. This phenomenon may be involved in clinically observed gender-dependent 
      differences in the frequency of both migraine and other trigeminal nerve-related 
      facial pain disorders.
FAU - Kuzawinska, Olga
AU  - Kuzawinska O
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Warsaw, Poland, ebalkowiec@wum.edu.pl.
FAU - Lis, Krzysztof
AU  - Lis K
FAU - Cudna, Agnieszka
AU  - Cudna A
FAU - Balkowiec-Iskra, Ewa
AU  - Balkowiec-Iskra E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Acta Neurobiol Exp (Wars)
JT  - Acta neurobiologiae experimentalis
JID - 1246675
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 9007-81-2 (Freund's Adjuvant)
RN  - JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Calcitonin Gene-Related Peptide/genetics/*metabolism
MH  - Cytokines/genetics/*metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - Freund's Adjuvant/toxicity
MH  - Gene Expression Regulation/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neuritis/chemically induced/*pathology
MH  - Neurons/*metabolism
MH  - *Sex Characteristics
MH  - Statistics, Nonparametric
MH  - Time Factors
MH  - Trigeminal Ganglion/*pathology
EDAT- 2014/07/06 06:00
MHDA- 2015/04/07 06:00
CRDT- 2014/07/05 06:00
PHST- 2014/07/05 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
AID - 1988 [pii]
AID - 10.55782/ane-2014-1988 [doi]
PST - ppublish
SO  - Acta Neurobiol Exp (Wars). 2014;74(2):227-32. doi: 10.55782/ane-2014-1988.