PMID- 24993663
OWN - NLM
STAT- MEDLINE
DCOM- 20151125
LR  - 20211021
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Print)
IS  - 0940-5429 (Linking)
VI  - 52
IP  - 1
DP  - 2015 Feb
TI  - Hyperactivation of working memory-related brain circuits in newly diagnosed 
      middle-aged type 2 diabetics.
PG  - 133-42
LID - 10.1007/s00592-014-0618-7 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is well known for its adverse impacts on brain 
      and cognition, which leads to multidimensional cognitive deficits and wildly 
      spread cerebral structure abnormalities. However, existing literatures are mainly 
      focused on patients with advanced age or extended T2DM duration. Therefore, it 
      remains unclear whether and how brain function would be affected at the initial 
      onset stage of T2DM in relatively younger population. In current study, twelve 
      newly diagnosed middle-aged T2DM patients with no previous diabetic treatment 
      history and twelve matched controls were recruited. Brain activations during a 
      working memory task, the digit n-back paradigm (0-, 1- and 2-back), were obtained 
      with functional magnetic resonance imaging and tested by repeated measures ANOVA. 
      Whereas patients performed the n-back task comparably well as controls, 
      significant load-by-group interactions of brain activation were found in the 
      right dorsolateral prefrontal cortex (DLPFC), left middle/inferior frontal gyrus, 
      and left parietal cortex, where patients exhibited hyperactivation in the 2-back, 
      but not the 0-back or 1-back condition compared to controls. Furthermore, the 
      severity of chronic hyperglycemia, estimated by glycosylated hemoglobin (HbA1c) 
      level, was entered into partial correlational analyses with task-related brain 
      activations, while controlling for the real-time influence of glucose, estimated 
      by instant plasma glucose level measured before scanning. Significant positive 
      correlations were found between HbA1c and brain activations in the anterior 
      cingulate cortex and bilateral DLPFC only in patients. Taken together, these 
      findings suggest there might be a compensatory mechanism due to brain 
      inefficiency related to chronic hyperglycemia at the initial onset stage of T2DM.
FAU - He, Xiao-Song
AU  - He XS
AD  - CAS Key Laboratory of Brain Function and Diseases, School of Life Science, 
      University of Science and Technology of China, 433 Huangshan Road, Hefei, 230027, 
      Anhui, China.
FAU - Wang, Zhao-Xin
AU  - Wang ZX
FAU - Zhu, You-Zhi
AU  - Zhu YZ
FAU - Wang, Nan
AU  - Wang N
FAU - Hu, Xiaoping
AU  - Hu X
FAU - Zhang, Da-Ren
AU  - Zhang DR
FAU - Zhu, De-Fa
AU  - Zhu DF
FAU - Zhou, Jiang-Ning
AU  - Zhou JN
LA  - eng
GR  - R01 EB002009/EB/NIBIB NIH HHS/United States
GR  - R01EB002009/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140704
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Brain/diagnostic imaging/*physiopathology
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/diagnosis/metabolism/physiopathology/*psychology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Memory, Short-Term
MH  - Middle Aged
MH  - Radiography
PMC - PMC4416650
MID - NIHMS611134
COIS- Conflict of Interest: Xiao-Song He, Zhao-Xin Wang, You-Zhi Zhu, Nan Wang, 
      Xiaoping Hu, Da-Ren Zhang, De-Fa Zhu, Jiang-Ning Zhou declare that they have no 
      conflict of interest.
EDAT- 2014/07/06 06:00
MHDA- 2015/12/15 06:00
PMCR- 2016/02/01
CRDT- 2014/07/05 06:00
PHST- 2014/03/17 00:00 [received]
PHST- 2014/06/16 00:00 [accepted]
PHST- 2014/07/05 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2016/02/01 00:00 [pmc-release]
AID - 10.1007/s00592-014-0618-7 [doi]
PST - ppublish
SO  - Acta Diabetol. 2015 Feb;52(1):133-42. doi: 10.1007/s00592-014-0618-7. Epub 2014 
      Jul 4.