PMID- 24994482
OWN - NLM
STAT- MEDLINE
DCOM- 20150810
LR  - 20141031
IS  - 1471-1788 (Electronic)
IS  - 1365-1501 (Linking)
VI  - 18
IP  - 4
DP  - 2014 Oct
TI  - Effect of methylphenidate treatment on appetite and levels of leptin, ghrelin, 
      adiponectin, and brain-derived neurotrophic factor in children and adolescents 
      with attention deficit and hyperactivity disorder.
PG  - 280-7
LID - 10.3109/13651501.2014.940054 [doi]
AB  - OBJECTIVES: We aimed to explore whether the use of methylphenidate relates 
      leptin, ghrelin, adiponectin, and brain-derived neurotrophic factor (BDNF). In 
      addition, the relationship between methylphenidate-related weight loss in 
      attention deficit hyperactivity disorder (ADHD) patients and these biomolecules 
      were evaluated. METHODS: Thirty ADHD patients receiving methylphenidate and 20 
      healthy controls were included. Leptin, ghrelin, adiponectin, and BDNF levels 
      were measured at baseline and after two-month treatment in both groups. RESULTS: 
      At baseline, leptin, ghrelin, adiponectin, and BDNF levels were similar in the 
      ADHD and control groups. The most common adverse events occurring in the ADHD 
      group after a 2-month treatment period included loss of appetite (70%) and weight 
      loss (66.7%). A significant difference was found in body weight, BMI, and CGI 
      scores of the ADHD patients after the treatment. While post-treatment ghrelin and 
      adiponectin levels were significantly higher in the ADHD group, BDNF level was 
      significantly lower. Post-treatment decrease in leptin levels was not 
      significant. CONCLUSIONS: Leptin and BDNF were not associated with poor appetite 
      and/or weight loss due to methylphenidate treatment. However, ghrelin and 
      adiponectin might be biomolecules that play a role in underlying neurobiological 
      mechanisms of methylphenidate-related appetite or weight loss.
FAU - Sahin, Serkan
AU  - Sahin S
AD  - Child and Adolescent Psychiatry Clinic, Balikesir Ataturk State Hospital , 
      Balikesir , Turkey.
FAU - Yuce, Murat
AU  - Yuce M
FAU - Alacam, Hasan
AU  - Alacam H
FAU - Karabekiroglu, Koray
AU  - Karabekiroglu K
FAU - Say, Gokce Nur
AU  - Say GN
FAU - Salis, Osman
AU  - Salis O
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140916
PL  - England
TA  - Int J Psychiatry Clin Pract
JT  - International journal of psychiatry in clinical practice
JID - 9709509
RN  - 0 (Adiponectin)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Ghrelin)
RN  - 0 (Leptin)
RN  - 207ZZ9QZ49 (Methylphenidate)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adolescent
MH  - Appetite/*drug effects
MH  - Attention Deficit Disorder with Hyperactivity/*blood/drug therapy
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Central Nervous System Stimulants/administration & 
      dosage/pharmacology/therapeutic use
MH  - Child
MH  - Delayed-Action Preparations/pharmacology/therapeutic use
MH  - Female
MH  - Ghrelin/*blood
MH  - Humans
MH  - Leptin/*blood
MH  - Male
MH  - Methylphenidate/administration & dosage/*pharmacology/therapeutic use
OTO - NOTNLM
OT  - Attention deficit hyperactivity disorder
OT  - adiponectin
OT  - brain-derived neurotrophic factor
OT  - ghrelin
OT  - leptin
OT  - methylphenidate
EDAT- 2014/07/06 06:00
MHDA- 2015/08/11 06:00
CRDT- 2014/07/05 06:00
PHST- 2014/07/05 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/08/11 06:00 [medline]
AID - 10.3109/13651501.2014.940054 [doi]
PST - ppublish
SO  - Int J Psychiatry Clin Pract. 2014 Oct;18(4):280-7. doi: 
      10.3109/13651501.2014.940054. Epub 2014 Sep 16.