PMID- 24994545
OWN - NLM
STAT- MEDLINE
DCOM- 20150211
LR  - 20140804
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 114
IP  - 4
DP  - 2014 Aug 15
TI  - Impact of long-term statin pretreatment on myocardial damage in ST elevation 
      myocardial infarction (from the AIDA STEMI CMR Substudy).
PG  - 503-9
LID - S0002-9149(14)01219-3 [pii]
LID - 10.1016/j.amjcard.2014.05.026 [doi]
AB  - Nonrandomized studies suggested lower mortality rates with statin pretreatment in 
      patients with acute ST elevation myocardial infarction (STEMI). However, clinical 
      data are still inconclusive and the mechanisms of these presumed beneficial 
      effects require further exploration. Cardiac magnetic resonance (CMR) imaging 
      offers the possibility of studying a variety of markers of myocardial damage and 
      reperfusion injury after myocardial infarction. The aim of this study was to 
      assess a possible link of statin pretreatment with myocardial damage in acute 
      STEMI. The multicenter Abciximab i.v. versus i.c. in ST-elevation Myocardial 
      Infarction CMR substudy enrolled 795 consecutive patients with acute STEMI who 
      underwent primary angioplasty within 12 hours of symptom onset. CMR studies 
      assessing left ventricular ejection fraction, infarct size, microvascular 
      obstruction, area at risk, and myocardial salvage index were performed in a 
      median of 3 days after the clinical event. We performed a retrospective analysis 
      to evaluate the impact of statin pretreatment on myocardial damage. Information 
      on statin pretreatment was available in 791 of 795 patients (99%). Of these, 122 
      (15%) had long-term statin pretreatment. CMR results showed no significant 
      differences in the area at risk, left ventricular ejection fraction, infarct 
      size, microvascular obstruction, and myocardial salvage index between patients 
      with and without statin pretreatment. Furthermore, no differences in short- and 
      long-term outcomes could be observed. In conclusion, in this CMR study, statin 
      pretreatment in patients with STEMI was not associated with lesser myocardial 
      damage.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Fuernau, Georg
AU  - Fuernau G
AD  - Department of Internal Medicine/Cardiology, University of Leipzig-Heart Center, 
      Leipzig, Germany. Electronic address: georg.fuernau@medizin.uni-leipzig.de.
FAU - Eitel, Ingo
AU  - Eitel I
AD  - Department of Internal Medicine/Cardiology, University of Leipzig-Heart Center, 
      Leipzig, Germany.
FAU - Wohrle, Jochen
AU  - Wohrle J
AD  - Department of Internal Medicine II-Cardiology, University of Ulm, Ulm, Germany.
FAU - Kerber, Sebastian
AU  - Kerber S
AD  - Department of Cardiology, Herz- und Gefass-Klinik Bad Neustadt, Bad Neustadt, 
      Germany.
FAU - Lauer, Bernward
AU  - Lauer B
AD  - Department of Cardiology, Zentralklinik Bad Berka, Bad Berka, Germany.
FAU - Pauschinger, Matthias
AU  - Pauschinger M
AD  - Medizinische Klinik/Kardiologie, Klinikum Nurnberg, Nurnberg, Germany.
FAU - Schwab, Johannes
AU  - Schwab J
AD  - Medizinische Klinik/Kardiologie, Klinikum Nurnberg, Nurnberg, Germany.
FAU - Birkemeyer, Ralf
AU  - Birkemeyer R
AD  - Department of Cardiology, University of Rostock, Rostock, Germany.
FAU - Pfeiffer, Stefan
AU  - Pfeiffer S
AD  - Medical Clinic I, Klinikum Pforzheim, Pforzheim, Germany.
FAU - Mende, Meinhard
AU  - Mende M
AD  - Clinical Trial Center Leipzig, University Leipzig, Leipzig, Germany.
FAU - Brosteanu, Oana
AU  - Brosteanu O
AD  - Clinical Trial Center Leipzig, University Leipzig, Leipzig, Germany.
FAU - Neuhaus, Petra
AU  - Neuhaus P
AD  - Clinical Trial Center Leipzig, University Leipzig, Leipzig, Germany.
FAU - Desch, Steffen
AU  - Desch S
AD  - Department of Internal Medicine/Cardiology, University of Leipzig-Heart Center, 
      Leipzig, Germany; Medical Clinic II, University of Lubeck, Lubeck, Germany.
FAU - de Waha, Suzanne
AU  - de Waha S
AD  - Department of Internal Medicine/Cardiology, University of Leipzig-Heart Center, 
      Leipzig, Germany; Department of Cardiology, Heart Center, Segeberger Kliniken, 
      Bad Segeberg, Germany.
FAU - Gutberlet, Matthias
AU  - Gutberlet M
AD  - Department of Diagnostic and Interventional Radiology, University of 
      Leipzig-Heart Center, Leipzig, Germany.
FAU - Schuler, Gerhard
AU  - Schuler G
AD  - Department of Internal Medicine/Cardiology, University of Leipzig-Heart Center, 
      Leipzig, Germany.
FAU - Thiele, Holger
AU  - Thiele H
AD  - Department of Internal Medicine/Cardiology, University of Leipzig-Heart Center, 
      Leipzig, Germany; Medical Clinic II, University of Lubeck, Lubeck, Germany.
LA  - eng
SI  - ClinicalTrials.gov/NCT00712101
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20140606
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
MH  - Aged
MH  - *Electrocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/diagnosis/*drug therapy/physiopathology
MH  - Prospective Studies
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2014/07/06 06:00
MHDA- 2015/02/12 06:00
CRDT- 2014/07/05 06:00
PHST- 2014/04/11 00:00 [received]
PHST- 2014/05/27 00:00 [revised]
PHST- 2014/05/27 00:00 [accepted]
PHST- 2014/07/05 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/02/12 06:00 [medline]
AID - S0002-9149(14)01219-3 [pii]
AID - 10.1016/j.amjcard.2014.05.026 [doi]
PST - ppublish
SO  - Am J Cardiol. 2014 Aug 15;114(4):503-9. doi: 10.1016/j.amjcard.2014.05.026. Epub 
      2014 Jun 6.