PMID- 2499506
OWN - NLM
STAT- MEDLINE
DCOM- 19890725
LR  - 20151029
IS  - 0741-0395 (Print)
IS  - 0741-0395 (Linking)
VI  - 6
IP  - 1
DP  - 1989
TI  - Characteristics of a multiplex IDDM sample: unexplained differences with other 
      samples.
PG  - 95-100
AB  - Characteristics of a multiplex sample of families with insulin-dependent diabetes 
      mellitus (IDDM) are studied and contrasted with similar characteristics in other, 
      more conventionally sampled data sets. Some characteristics remain consistent 
      with earlier observations including the high frequency of human leukocyte antigen 
      (HLA) DR3,4 in affected individuals and the greater than expected percentage of 
      HLA haplotype sharing among affected sib pairs. In other respects, however, 
      differences are seen between this sample and others. "Control" haplotypes, i.e., 
      those not transmitted to the first affected offspring, had a higher frequency of 
      DR3 and DR4 than expected, and a rather high frequency of affected parents was 
      observed. Differences between the first affected and later affected offspring 
      reported in other samples were absent from these families. No effect of the 
      sampling scheme and the resulting distribution of parental phenotypes could be 
      shown to explain this difference.
FAU - Falk, C T
AU  - Falk CT
AD  - Department of Population Genetics, New York Blood Center, New York 10021.
LA  - eng
GR  - GM29177/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genet Epidemiol
JT  - Genetic epidemiology
JID - 8411723
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (HLA-DR4 Antigen)
SB  - IM
MH  - Child
MH  - Diabetes Mellitus, Type 1/epidemiology/*genetics
MH  - *Gene Frequency
MH  - *Genes, MHC Class II
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DR3 Antigen
MH  - HLA-DR4 Antigen
MH  - Humans
MH  - Risk Factors
MH  - Sampling Studies
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1002/gepi.1370060118 [doi]
PST - ppublish
SO  - Genet Epidemiol. 1989;6(1):95-100. doi: 10.1002/gepi.1370060118.