PMID- 24995346
OWN - NLM
STAT- MEDLINE
DCOM- 20150223
LR  - 20221207
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2014
DP  - 2014
TI  - Distribution of HLA-A, -B, and -C alleles and HLA/KIR combinations in Han 
      population in China.
PG  - 565296
LID - 10.1155/2014/565296 [doi]
LID - 565296
AB  - We investigated polymorphisms of the human leukocyte antigen (HLA) class I (A, B, 
      and C) loci of a Han population (n, 239) from the Yunnan province, Southwest 
      China, using high-resolution polymerase chain reaction-Luminex (PCR-Luminex) 
      typing. We combined the HLA data from this study with the KIR genotypes from a 
      previous study of this Han population to analyze the combination of KIR/HLA 
      ligands. A total of 27 HLA-A, 54 HLA-B, and 31 HLA-C alleles were found in this 
      population. The frequencies of A*11:01, A*24:02, B*40:01, B*46:01, C*01:02, 
      C*03:04, and C*07:02 were all > 10%. The following haplotypes were common, with 
      frequencies > 5%: 1 A-B (A*02:07-B*46:01), 2 A-C (A*02:07-C*01:02, and 
      A*11:01-C*07:02), 4 C-B (B*13:01-C*03:04, B*40:01-C*07:02, B*46:01-C*01:02 and 
      B*58:01-C*03:02), and 1 A-C-B (A*02:07-C*01:02-B*46:01). Analysis of KIR3D and 
      their ligands HLA-A3/A11 and HLA-Bw4 showed that the frequencies of 
      3DL2(+)-A3/A11(+) and 3DL2(+)-A3/A11(-) were 0.527 and 0.473, and the frequencies 
      of 3DL1(+)-Bw4(+), 3DL1(+)-Bw4(-), 3DL1(-)-Bw4(+), and 3DL1(-)-Bw4(-) were 0.552, 
      0.397, 0.038, and 0.013, respectively. The results of KIR/HLA-C combination 
      analysis showed that all individuals had at least one inhibitory or activating 
      KIR/HLA-C pair, and one KIR/HLA-C pair was the most frequent (157/239), followed 
      by two pairs (46/239), three pairs (33/239), and no pairs (3/239). Comparison of 
      KIR gene and HLA gene and their pair frequency between Yunnan Han and the 
      isolated Han (FYDH) who also lived in Yunnan province showed no significant 
      difference (P > 0.05) in KIR frequencies, but significant differences (P < 0.05) 
      for some HLA allele frequencies. In addition, there was no significant difference 
      (P > 0.05) between the two populations for KIR/HLA pairs.
FAU - Shen, Yunsong
AU  - Shen Y
AD  - The First People's Hospital in Yunnan Province and The Affiliated Hospital of 
      Kunming Science and Technology University, Kunming 650032, China.
FAU - Cao, Danfeng
AU  - Cao D
AD  - Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious 
      Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences 
      (CAMS) and Peking Union Medical College (PUMC), Kunming 650118, China.
FAU - Li, Yalin
AU  - Li Y
AD  - The First People's Hospital in Yunnan Province and The Affiliated Hospital of 
      Kunming Science and Technology University, Kunming 650032, China.
FAU - Kulski, J K
AU  - Kulski JK
AD  - The Centre for Forensic Science, University of Western Australia, Nedlands, WA 
      6009, Australia.
FAU - Shi, Lei
AU  - Shi L
AD  - Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious 
      Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences 
      (CAMS) and Peking Union Medical College (PUMC), Kunming 650118, China.
FAU - Jiang, Hongjun
AU  - Jiang H
AD  - The First People's Hospital in Yunnan Province and The Affiliated Hospital of 
      Kunming Science and Technology University, Kunming 650032, China.
FAU - Ma, Qianli
AU  - Ma Q
AD  - The No. 3 Affiliated Hospital of Kunming Medical University, Kunming 650118, 
      China.
FAU - Yu, Jiankun
AU  - Yu J
AD  - Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious 
      Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences 
      (CAMS) and Peking Union Medical College (PUMC), Kunming 650118, China.
FAU - Zhou, Jingxian
AU  - Zhou J
AD  - Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious 
      Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences 
      (CAMS) and Peking Union Medical College (PUMC), Kunming 650118, China.
FAU - Yao, Yufeng
AU  - Yao Y
AD  - Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious 
      Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences 
      (CAMS) and Peking Union Medical College (PUMC), Kunming 650118, China.
FAU - Shi, Li
AU  - Shi L
AD  - Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious 
      Diseases, Institute of Medical Biology, Chinese Academy of Medical Sciences 
      (CAMS) and Peking Union Medical College (PUMC), Kunming 650118, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140609
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Ligands)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Alleles
MH  - Asian People/*genetics
MH  - China
MH  - Gene Frequency
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - Haplotypes
MH  - Heterozygote
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Ligands
MH  - Linkage Disequilibrium
MH  - *Polymorphism, Genetic
MH  - Receptors, KIR/*genetics
PMC - PMC4068047
EDAT- 2014/07/06 06:00
MHDA- 2015/02/24 06:00
PMCR- 2014/06/09
CRDT- 2014/07/05 06:00
PHST- 2014/01/06 00:00 [received]
PHST- 2014/05/09 00:00 [revised]
PHST- 2014/05/23 00:00 [accepted]
PHST- 2014/07/05 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
PHST- 2014/06/09 00:00 [pmc-release]
AID - 10.1155/2014/565296 [doi]
PST - ppublish
SO  - J Immunol Res. 2014;2014:565296. doi: 10.1155/2014/565296. Epub 2014 Jun 9.