PMID- 24996373 OWN - NLM STAT- MEDLINE DCOM- 20160915 LR - 20211021 IS - 1615-2573 (Electronic) IS - 0910-8327 (Print) IS - 0910-8327 (Linking) VI - 30 IP - 6 DP - 2015 Nov TI - Characteristics and clinical relevance of late gadolinium enhancement in cardiac magnetic resonance in patients with systemic sclerosis. PG - 779-88 LID - 10.1007/s00380-014-0539-y [doi] AB - Cardiac involvement in systemic sclerosis (SSc) is considerably frequent in autopsy, but the early identification is clinically difficult. Recent advantages in cardiac magnetic resonance (CMR) enabled to detect myocardial fibrotic scar as late gadolinium enhancement (LGE). We aimed to examine the prevalence and distribution of LGE in patients with SSc, and associate them with clinical features, electrocardiographic abnormalities and cardiac function. Forty patients with SSc (58 +/- 14 years-old, 35 females, limited/diffuse 25/15, disease duration 106 +/- 113 months) underwent serological tests, 12-lead electrocardiogram (ECG) and CMR. Seven patients (17.5 %) showed LGE in 26 segments of left ventricle (LV). LGE distributed mainly in the basal to mid inter-ventricular septum and the right ventricular (RV) insertion points, but involved all the myocardial regions. More patients with LGE showed NYHA functional class II and more (71 vs. 21 %, p < 0.05), bundle branch blocks (57 vs. 6 %, p < 0.05), LV ejection fraction (LVEF) < 50 % (72 vs. 6 %, p < 0.01), LV asynergy (43 vs. 0 %, p < 0.01) and RVEF < 40 % (100 vs. 39 %, p < 0.01). There was no difference in disease duration, disease types, or prevalence of positive autoimmune antibodies or high serum NT-proBNP level (>125 pg/ml). When cardiac involvement of SSc was defined as low LVEF, ECG abnormalities or high NT-proBNP, the sensitivity, specificity positive and negative predictive values of LGE were 36, 92, 71 and 72 %, respectively. We could clarify the prevalence and distribution of LGE in Japanese patients with SSc. The presence of LGE was associated with cardiac symptom, conduction disturbance and impaired LV/RV contraction. FAU - Sano, Makoto AU - Sano M AD - Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, Hamamatsu, 431-3192, Japan. FAU - Satoh, Hiroshi AU - Satoh H AD - Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, Hamamatsu, 431-3192, Japan. satoh36@hama-med.ac.jp. FAU - Suwa, Kenichiro AU - Suwa K AD - Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, Hamamatsu, 431-3192, Japan. FAU - Nobuhara, Mamoru AU - Nobuhara M AD - Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, Hamamatsu, 431-3192, Japan. FAU - Saitoh, Takeji AU - Saitoh T AD - Department of Emergency Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan. FAU - Saotome, Masao AU - Saotome M AD - Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, Hamamatsu, 431-3192, Japan. FAU - Urushida, Tsuyoshi AU - Urushida T AD - Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, Hamamatsu, 431-3192, Japan. FAU - Katoh, Hideki AU - Katoh H AD - Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, Hamamatsu, 431-3192, Japan. FAU - Shimoyama, Kumiko AU - Shimoyama K AD - Division of Immunology and Rheumatology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan. FAU - Suzuki, Daisuke AU - Suzuki D AD - Division of Immunology and Rheumatology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan. FAU - Ogawa, Noriyoshi AU - Ogawa N AD - Division of Immunology and Rheumatology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan. FAU - Takehara, Yasuo AU - Takehara Y AD - Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu, Japan. FAU - Sakahara, Harumi AU - Sakahara H AD - Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu, Japan. FAU - Hayashi, Hideharu AU - Hayashi H AD - Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ward, Hamamatsu, 431-3192, Japan. LA - eng PT - Journal Article DEP - 20140705 PL - Japan TA - Heart Vessels JT - Heart and vessels JID - 8511258 RN - 0 (Contrast Media) RN - 0 (Peptide Fragments) RN - 0 (pro-brain natriuretic peptide (1-76)) RN - 114471-18-0 (Natriuretic Peptide, Brain) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Cardiomyopathies/*diagnosis MH - *Contrast Media MH - Electrocardiography MH - Female MH - *Gadolinium MH - Humans MH - *Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Myocardium/pathology MH - Natriuretic Peptide, Brain/*blood MH - Peptide Fragments/*blood MH - Predictive Value of Tests MH - Scleroderma, Systemic/*complications MH - Ventricular Function, Left MH - Young Adult PMC - PMC4648959 OTO - NOTNLM OT - Cardiac function OT - Conduction disturbance OT - Electrocardiography OT - Late gadolinium enhancement OT - Systemic scleroderma EDAT- 2014/07/06 06:00 MHDA- 2016/09/16 06:00 PMCR- 2014/07/05 CRDT- 2014/07/06 06:00 PHST- 2014/02/16 00:00 [received] PHST- 2014/06/13 00:00 [accepted] PHST- 2014/07/06 06:00 [entrez] PHST- 2014/07/06 06:00 [pubmed] PHST- 2016/09/16 06:00 [medline] PHST- 2014/07/05 00:00 [pmc-release] AID - 10.1007/s00380-014-0539-y [pii] AID - 539 [pii] AID - 10.1007/s00380-014-0539-y [doi] PST - ppublish SO - Heart Vessels. 2015 Nov;30(6):779-88. doi: 10.1007/s00380-014-0539-y. Epub 2014 Jul 5.