PMID- 24996689
OWN - NLM
STAT- MEDLINE
DCOM- 20141112
LR  - 20161125
IS  - 1532-8392 (Electronic)
IS  - 0046-8177 (Linking)
VI  - 45
IP  - 9
DP  - 2014 Sep
TI  - Benign lipomatous masses of the heart: a comprehensive series of 47 cases with 
      cytogenetic evaluation.
PG  - 1859-65
LID - S0046-8177(14)00207-X [pii]
LID - 10.1016/j.humpath.2014.05.003 [doi]
AB  - Benign lipomatous lesions of the heart encompass an apparently etiologically 
      diverse group of entities including neoplastic, congenital, and reparative 
      phenomena. Among these, lipomas and lipomatous hypertrophy of the atrial septum 
      (LHAS) represent 2 commonly encountered mass lesions. To date, no study has 
      systematically and comparatively evaluated the morphologic and genetic 
      characteristics of these lesions. Tissue registry archives of Mayo Clinic were 
      queried for cases of cardiac lipoma and LHAS (1994-2011). Clinical, imaging, and 
      pathologic findings were reviewed. Representative cases in each cohort were 
      evaluated by fluorescence in situ hybridization (FISH) for HMGA1 and HMGA2 loci 
      rearrangement and for MDM2/CPM locus amplification. Five cases of cardiac lipoma 
      were identified (mean age, 67 years; range, 48-101; 3 men): 4 right atrial and 1 
      left ventricular. Forty-two cases of LHAS were identified (mean age, 75.6 years; 
      range 45-95; 20 men), 39 of which were autopsy derived. The median size was 3.4 
      cm for lipomas and 2.8 cm for LHAS (n = 14). A single case each of cardiac lipoma 
      and LHAS were found to harbor HMGA2 rearrangement, whereas no case showed 
      cytogenetic abnormality of HMGA1 or CPM. This represents the largest series of 
      histopathologically confirmed cardiac lipomas from a single institution. In 
      addition, it is the first to evaluate cardiac lipomas and LHAS for genetic 
      alterations associated with extracardiac lipomatous lesions. The genetic and 
      morphologic similarities found provide evidence in support of the neoplastic 
      classification of cardiac lipomas. A single case of LHAS contained an HMGA2 
      rearrangement, challenging the currently accepted hypothesis of pathogenesis for 
      this lesion.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Bois, Melanie C
AU  - Bois MC
AD  - Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905.
FAU - Bois, John P
AU  - Bois JP
AD  - Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905.
FAU - Anavekar, Nandan S
AU  - Anavekar NS
AD  - Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905.
FAU - Oliveira, Andre M
AU  - Oliveira AM
AD  - Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905.
FAU - Maleszewski, Joseph J
AU  - Maleszewski JJ
AD  - Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905. Electronic 
      address: maleszewski.joseph@mayo.edu.
LA  - eng
PT  - Journal Article
DEP - 20140523
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (HMGA2 Protein)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Atrial Septum/diagnostic imaging/pathology
MH  - Cytogenetic Analysis
MH  - Demography
MH  - Diagnosis, Differential
MH  - Female
MH  - Gene Rearrangement
MH  - HMGA2 Protein/*genetics
MH  - Heart Diseases/diagnosis/*genetics/pathology
MH  - Heart Neoplasms/diagnosis/*genetics/pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lipoma/diagnosis/*genetics/pathology
MH  - Lipomatosis/diagnosis/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Radiography
MH  - Retrospective Studies
MH  - Ultrasonography
OTO - NOTNLM
OT  - Fatty infiltration
OT  - Hibernoma
OT  - Lipoma
OT  - Lipomatous hypertrophy of the atrial septum
OT  - Lipomatous hypertrophy of the interatrial septum
EDAT- 2014/07/06 06:00
MHDA- 2014/11/13 06:00
CRDT- 2014/07/06 06:00
PHST- 2014/03/24 00:00 [received]
PHST- 2014/05/01 00:00 [revised]
PHST- 2014/05/07 00:00 [accepted]
PHST- 2014/07/06 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2014/11/13 06:00 [medline]
AID - S0046-8177(14)00207-X [pii]
AID - 10.1016/j.humpath.2014.05.003 [doi]
PST - ppublish
SO  - Hum Pathol. 2014 Sep;45(9):1859-65. doi: 10.1016/j.humpath.2014.05.003. Epub 2014 
      May 23.