PMID- 24997359
OWN - NLM
STAT- MEDLINE
DCOM- 20150528
LR  - 20151119
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 394
IP  - 1-2
DP  - 2014 Aug 25
TI  - Maternal and fetal metabonomic alterations in prenatal nicotine exposure-induced 
      rat intrauterine growth retardation.
PG  - 59-69
LID - S0303-7207(14)00199-3 [pii]
LID - 10.1016/j.mce.2014.06.016 [doi]
AB  - Prenatal nicotine exposure causes adverse birth outcome. However, the 
      corresponding metabonomic alterations and underlying mechanisms of 
      nicotine-induced developmental toxicity remain unclear. The aims of this study 
      were to characterize the metabolic alterations in biofluids in nicotine-induced 
      intrauterine growth retardation (IUGR) rat model. In the present study, pregnant 
      Wistar rats were intragastrically administered with different doses of nicotine 
      (0.5, 1.0 and 2.0 mg/kg d) from gestational day (GD) 11-20. The metabolic 
      profiles of the biofluids, including maternal plasma, fetal plasma and amniotic 
      fluid, were analyzed using (1)H nuclear magnetic resonance (NMR)-based 
      metabonomic techniques. Prenatal nicotine exposure caused noticeably lower body 
      weights, higher IUGR rates of fetal rats, and elevated maternal and fetal 
      corticosterone (CORT) levels compared to the controls. The correlation analysis 
      among maternal, fetal serum CORT levels and fetal bodyweight suggested that the 
      levels of maternal and fetal serum CORT presented a positive correlation 
      (r=0.356, n=32, P<0.05), while there was a negative correlation between fetal 
      (r=-0.639, n=32, P<0.01) and maternal (r=-0.530, n=32, P<0.01) serum CORT level 
      and fetal bodyweight. The fetal metabonome alterations included the stimulation 
      of lipogenesis and the decreased levels of glucose and amino acids. The maternal 
      metabonome alterations involved the enhanced blood glucose levels, fatty acid 
      oxygenolysis, proteolysis and amino acid accumulation. These results suggested 
      that prenatal nicotine exposure is associated with an altered maternal and fetal 
      metabonome, which may be related to maternal increased glucocorticoid level 
      induced by nicotine.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Feng, Jiang-hua
AU  - Feng JH
AD  - Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and 
      Magnetic Resonance, Xiamen University, Xiamen 361005, China. Electronic address: 
      jianghua.feng@xmu.edu.cn.
FAU - Yan, You-e
AU  - Yan YE
AD  - Department of Pharmacology, School of Basic Medical Science, Wuhan University, 
      Wuhan 430071, China.
FAU - Liang, Gai
AU  - Liang G
AD  - Department of Pharmacology, School of Basic Medical Science, Wuhan University, 
      Wuhan 430071, China.
FAU - Liu, Yan-song
AU  - Liu YS
AD  - Department of Pharmacology, School of Basic Medical Science, Wuhan University, 
      Wuhan 430071, China.
FAU - Li, Xiao-jun
AU  - Li XJ
AD  - Department of Pharmacology, School of Basic Medical Science, Wuhan University, 
      Wuhan 430071, China.
FAU - Zhang, Ben-jian
AU  - Zhang BJ
AD  - Department of Pharmacology, School of Basic Medical Science, Wuhan University, 
      Wuhan 430071, China.
FAU - Chen, Liao-bin
AU  - Chen LB
AD  - Research Center of Food and Drug Evaluation, Wuhan University, Wuhan 430071, 
      China.
FAU - Yu, Hong
AU  - Yu H
AD  - Research Center of Food and Drug Evaluation, Wuhan University, Wuhan 430071, 
      China.
FAU - He, Xiao-hua
AU  - He XH
AD  - Research Center of Food and Drug Evaluation, Wuhan University, Wuhan 430071, 
      China.
FAU - Wang, Hui
AU  - Wang H
AD  - Department of Pharmacology, School of Basic Medical Science, Wuhan University, 
      Wuhan 430071, China; Research Center of Food and Drug Evaluation, Wuhan 
      University, Wuhan 430071, China. Electronic address: wanghui19@whu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140703
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Amino Acids)
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids)
RN  - 6M3C89ZY6R (Nicotine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Amino Acids/metabolism
MH  - Amniotic Fluid/chemistry
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Corticosterone/blood
MH  - Fatty Acids/metabolism
MH  - Female
MH  - Fetal Growth Retardation/chemically induced/*metabolism/pathology
MH  - Fetal Weight/drug effects
MH  - Fetus/*drug effects/pathology
MH  - Gestational Age
MH  - Lipogenesis
MH  - Male
MH  - *Maternal Exposure
MH  - *Metabolomics
MH  - Nicotine/*toxicity
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Biomarker
OT  - Intrauterine growth retardation
OT  - Metabonomics
OT  - Nicotine
OT  - Nuclear magnetic resonance
EDAT- 2014/07/06 06:00
MHDA- 2015/05/29 06:00
CRDT- 2014/07/06 06:00
PHST- 2014/03/20 00:00 [received]
PHST- 2014/06/14 00:00 [revised]
PHST- 2014/06/20 00:00 [accepted]
PHST- 2014/07/06 06:00 [entrez]
PHST- 2014/07/06 06:00 [pubmed]
PHST- 2015/05/29 06:00 [medline]
AID - S0303-7207(14)00199-3 [pii]
AID - 10.1016/j.mce.2014.06.016 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2014 Aug 25;394(1-2):59-69. doi: 10.1016/j.mce.2014.06.016. 
      Epub 2014 Jul 3.