PMID- 24997471
OWN - NLM
STAT- MEDLINE
DCOM- 20150611
LR  - 20161229
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 127
IP  - 1
DP  - 2014 Oct
TI  - Prognostic factors of primary fallopian tube cancer in a single institute in 
      Taiwan.
PG  - 77-81
LID - S0020-7292(14)00306-3 [pii]
LID - 10.1016/j.ijgo.2014.04.018 [doi]
AB  - OBJECTIVE: To improve the understanding of primary fallopian tube carcinoma 
      (PFTC) through an analysis of possible clinical and pathologic determinants of 
      prognosis. METHODS: A retrospective review of the database of a tertiary hospital 
      in Taiwan for 1978-2007 was conducted to identify patients with a diagnosis of 
      PFTC and to evaluate the clinicopathologic features associated with PFTC outcome. 
      RESULTS: Fifty-eight patients (mean age 62.5 years) had a diagnosis of PFTC. 
      Stage III/IV disease (55%) and poorly differentiated tumors (52%) were most 
      common. The median follow-up was 93 months (range, 11-333 months). The 5-year 
      disease-free survival rate was 59%, and the overall survival rate was 64%. 
      Factors important in disease-free and overall survival in univariate analysis 
      included the presence of pelvic and/or para-aortic lymph node metastases, 
      International Federation of Gynecology and Obstetrics stage, high preoperative 
      carbohydrate antigen 125 serum level, completion of optimal debulking surgery, 
      and the use of paclitaxel-based chemotherapy; however, only patients with optimal 
      cytoreduction had a decreased hazard of recurrence (hazard ratio [HR] 0.06; 95% 
      confidence interval [CI] 0.01-0.23) and mortality (HR 0.08; 95% CI, 0.02-0.31) in 
      multivariate analysis. CONCLUSION: Advanced tumor stage, in particular the 
      presence of lymph node metastases, worsened the prognosis of patients with PFTC. 
      However, optimal debulking surgery significantly improved the prognosis, 
      emphasizing the importance of the treatment strategy.
CI  - Copyright (c) 2014 International Federation of Gynecology and Obstetrics. Published 
      by Elsevier Ireland Ltd. All rights reserved.
FAU - Horng, Huann-Cheng
AU  - Horng HC
AD  - Division of Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans 
      General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, 
      National Yang-Ming University School of Medicine, Taipei, Taiwan.
FAU - Teng, Sen-Wen
AU  - Teng SW
AD  - Department of Obstetrics and Gynecology, Cardinal Tien Hospital-Hsintien, New 
      Taipei City, Taiwan; Department of Obstetrics and Gynecology, Fu Jen Catholic 
      University, New Taipei City, Taiwan.
FAU - Lai, Chiung-Ru
AU  - Lai CR
AD  - Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan; 
      Department of Pathology, National Yang-Ming University, Taipei, Taiwan.
FAU - Chang, Wen-Hsu
AU  - Chang WH
AD  - Department of Nursing, Taipei Veterans General Hospital, Taipei, Taiwan; 
      Department of Nursing, National Yang-Ming University School of Nursing, Taipei, 
      Taiwan.
FAU - Chang, Yen-Hou
AU  - Chang YH
AD  - Division of Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans 
      General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, 
      National Yang-Ming University School of Medicine, Taipei, Taiwan.
FAU - Yen, Ming-Shyen
AU  - Yen MS
AD  - Division of Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans 
      General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, 
      National Yang-Ming University School of Medicine, Taipei, Taiwan.
FAU - Wang, Peng-Hui Peter
AU  - Wang PH
AD  - Division of Gynecology, Department of Obstetrics and Gynecology, Taipei Veterans 
      General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, 
      National Yang-Ming University School of Medicine, Taipei, Taiwan; Immunology 
      Center, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Medical 
      Research, China Medical University Hospital, Taichung, Taiwan; Infection and 
      Immunity Research, National Yang-Ming University, Taipei, Taiwan. Electronic 
      address: phwang@vghtpe.gov.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140619
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the 
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma/*mortality/pathology
MH  - Fallopian Tube Neoplasms/*mortality/pathology
MH  - Fallopian Tubes/pathology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Taiwan/epidemiology
OTO - NOTNLM
OT  - Outcome
OT  - Primary fallopian tube carcinoma
OT  - Prognosis
OT  - Taiwan
EDAT- 2014/07/07 06:00
MHDA- 2015/06/13 06:00
CRDT- 2014/07/07 06:00
PHST- 2013/12/17 00:00 [received]
PHST- 2014/04/09 00:00 [revised]
PHST- 2014/06/04 00:00 [accepted]
PHST- 2014/07/07 06:00 [entrez]
PHST- 2014/07/07 06:00 [pubmed]
PHST- 2015/06/13 06:00 [medline]
AID - S0020-7292(14)00306-3 [pii]
AID - 10.1016/j.ijgo.2014.04.018 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2014 Oct;127(1):77-81. doi: 10.1016/j.ijgo.2014.04.018. 
      Epub 2014 Jun 19.