PMID- 24997826
OWN - NLM
STAT- MEDLINE
DCOM- 20150115
LR  - 20181202
IS  - 1000-503X (Print)
IS  - 1000-503X (Linking)
VI  - 36
IP  - 3
DP  - 2014 Jun
TI  - Effect of piglitazone and metformin on retinol-binding protein-4 and adiponectin 
      in patients with type 2 diabetes mellitus complicated with non-alcohol fatty acid 
      liver diseases.
PG  - 309-12
LID - 10.3881/j.issn.1000-503X.2014.03.015 [doi]
AB  - OBJECTIVE: To compare the effects of piglitazone and metformin on retinol-binding 
      protein-4 (RBP-4) and adiponcetin (APN) in patients with type 2 diabetes mellitus 
      (T2DM) complicated with Non alcohol fatty acid liver disease (NAFLD). METHODS: 
      Totally 60 T2DM patients complicated with NAFLD were equally and randomly divided 
      into pioglitazone group and metform group. The levels of biochemical indicators 
      including body mass index (BMI), glucose hemoglobin A1C (GHbA1C), insulin 
      resistance (HOMA-IR), fasting blood glucose (FBG), fasting insulin (FIns), and 
      serum triglycerides (TG) as well as serum RBP-4 and APN level were measured 
      pre-treatment and 12 weeks after treatments. RESULTS: After 12 weeks of 
      treaments, BMI, FBG, HOMA-IR, GHbA1C, FIns, and TG decreased (all P<0.05) in both 
      piglitazone group and metform group. APN increased (all P<0.05) in both groups. 
      RBP-4 decreased (P<0.05) in piglitazone group. Compare with the metform group, 
      the levels of RBP-4, FIns ,and HOMA-IR decreased and BMI increased in piglitazone 
      group (P<0.05). CONCLUSION: Piglitazone is superior to metoform in decreasing 
      RBP-4 level and HOMA-IR in patients with T2DM complicated with NAFLD.
FAU - Yang, Lu
AU  - Yang L
AD  - Department of Endocrinolgy,Affliated Hospital of Hangzhou Normal 
      University,Hangzhou 310015,China.
FAU - Song, Mei-qing
AU  - Song MQ
AD  - Department of Endocrinolgy,Affliated Hospital of Hangzhou Normal 
      University,Hangzhou 310015,China.
FAU - Zhang, Qiu-ling
AU  - Zhang QL
AD  - Department of Endocrinolgy,Affliated Hospital of Hangzhou Normal 
      University,Hangzhou 310015,China.
FAU - Shou, Lan
AU  - Shou L
AD  - Department of Endocrinolgy,Affliated Hospital of Hangzhou Normal 
      University,Hangzhou 310015,China.
FAU - Zang, Shu-fei
AU  - Zang SF
AD  - Department of Endocrinolgy,Affliated Hospital of Hangzhou Normal 
      University,Hangzhou 310015,China.
FAU - Yang, Yan-li
AU  - Yang YL
AD  - Department of Endocrinolgy,Affliated Hospital of Hangzhou Normal 
      University,Hangzhou 310015,China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao
JT  - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
JID - 8006230
RN  - 0 (Adiponectin)
RN  - 0 (RBP4 protein, human)
RN  - 0 (Retinol-Binding Proteins, Plasma)
RN  - 0 (Thiazolidinediones)
RN  - 9100L32L2N (Metformin)
RN  - X4OV71U42S (Pioglitazone)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adult
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*blood/complications/drug therapy
MH  - Fatty Liver/blood/complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Metformin/*pharmacology
MH  - Middle Aged
MH  - Pioglitazone
MH  - Retinol-Binding Proteins, Plasma/*metabolism
MH  - Thiazolidinediones/*pharmacology
EDAT- 2014/07/07 06:00
MHDA- 2015/01/16 06:00
CRDT- 2014/07/07 06:00
PHST- 2014/07/07 06:00 [entrez]
PHST- 2014/07/07 06:00 [pubmed]
PHST- 2015/01/16 06:00 [medline]
AID - 10.3881/j.issn.1000-503X.2014.03.015 [doi]
PST - ppublish
SO  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2014 Jun;36(3):309-12. doi: 
      10.3881/j.issn.1000-503X.2014.03.015.