PMID- 24998350
OWN - NLM
STAT- MEDLINE
DCOM- 20150515
LR  - 20211021
IS  - 2042-0226 (Electronic)
IS  - 1672-7681 (Print)
IS  - 1672-7681 (Linking)
VI  - 11
IP  - 5
DP  - 2014 Sep
TI  - HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for 
      reproduction.
PG  - 460-6
LID - 10.1038/cmi.2014.53 [doi]
AB  - The uterus in early pregnancy is a non-lymphoid organ that is enriched in natural 
      killer (NK) cells. Studies to address the role of these abundant human NK cells 
      at the maternal/fetal interface have focused on their response to the major 
      histocompatibility complex (MHC) molecules on fetal trophoblast cells that they 
      contact. The interaction of maternal NK cell receptors belonging to the killer 
      cell immunoglobulin-like receptor (KIR) family with trophoblast MHC class I 
      molecules in pregnancy can regulate NK cell activation for secretion of 
      pro-angiogenic factors that promote placental development. This review will cover 
      the role of KIR at the maternal/fetal interface and focus on KIR2DL4, a KIR 
      family member that is uniquely poised to play a role in pregnancy due to the 
      restricted expression of its ligand, human leukocyte antigen (HLA)-G, by fetal 
      trophoblast cells early in pregnancy. The pathways by which KIR2DL4-HLA-G 
      interactions induce the cellular senescence of NK cells and the role of the 
      resulting senescence-associated secretory phenotype (SASP) in vascular remodeling 
      will be discussed in the context of reproduction.
FAU - Rajagopalan, Sumati
AU  - Rajagopalan S
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
DEP - 20140707
PL  - China
TA  - Cell Mol Immunol
JT  - Cellular & molecular immunology
JID - 101242872
RN  - 0 (Drug Combinations)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Hydroxyprogesterones)
RN  - 0 (KIR2DL4 protein, human)
RN  - 0 (Receptors, KIR2DL4)
RN  - 4TI98Z838E (Estradiol)
RN  - 6PG9VR430D (Nandrolone)
RN  - 87533-94-6 (trophobolen)
SB  - IM
MH  - Animals
MH  - Cellular Senescence
MH  - Drug Combinations
MH  - Estradiol/analogs & derivatives/immunology
MH  - Female
MH  - HLA-G Antigens/*immunology
MH  - Humans
MH  - Hydroxyprogesterones/immunology
MH  - Killer Cells, Natural/*immunology
MH  - Nandrolone/analogs & derivatives/immunology
MH  - Pregnancy
MH  - Receptors, KIR2DL4/*immunology
MH  - Reproduction/*immunology
MH  - Uterus/immunology
MH  - Vascular Remodeling/*immunology
PMC - PMC4197210
EDAT- 2014/07/08 06:00
MHDA- 2015/05/16 06:00
PMCR- 2014/09/01
CRDT- 2014/07/08 06:00
PHST- 2014/05/01 00:00 [received]
PHST- 2014/06/04 00:00 [revised]
PHST- 2014/06/04 00:00 [accepted]
PHST- 2014/07/08 06:00 [entrez]
PHST- 2014/07/08 06:00 [pubmed]
PHST- 2015/05/16 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - cmi201453 [pii]
AID - 10.1038/cmi.2014.53 [doi]
PST - ppublish
SO  - Cell Mol Immunol. 2014 Sep;11(5):460-6. doi: 10.1038/cmi.2014.53. Epub 2014 Jul 
      7.