PMID- 24999119
OWN - NLM
STAT- MEDLINE
DCOM- 20150821
LR  - 20200106
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 38
DP  - 2014 Nov
TI  - Umbilical cord blood mesenchymal stem cells co-modified by TERT and BDNF: a novel 
      neuroprotective therapy for neonatal hypoxic-ischemic brain damage.
PG  - 147-54
LID - S0736-5748(14)00096-3 [pii]
LID - 10.1016/j.ijdevneu.2014.06.014 [doi]
AB  - Hypoxic-ischemic brain damage (HIBD), a leading cause of perinatal disability and 
      death, has limited therapeutic options. Stem cell therapy has been demonstrated 
      as a potential novel therapy for neurological disorders. Compared with other 
      types of stem cells, umbilical cord blood mesenchymal stem cells (UCB-MSCs) have 
      several unique characteristics, such as a higher rate of cell proliferation and 
      clonality. However, the limited life span of UCB-MSCs hinders their clinical 
      application. Therefore, efforts are urgently needed to circumvent this 
      disadvantage. Telomerase reverse transcriptase (TERT), which promotes cell 
      proliferation and survival, plays a protective role in hypoxic-ischemic (HI) 
      brain injury. Thus, it is reasonable to propose that UCB-MSCs modified by 
      exogenous TERT expression might have a longer lifespan and increased viability. 
      Moreover, brain-derived neurotrophic factor (BDNF), a neurotrophin that regulates 
      development, regeneration, survival and maintenance of neurons, facilitates 
      post-injury recovery when administered by infusion or virus-mediated delivery. 
      Therefore, TERT- and BDNF-modified UCB-MSCs may have a longer lifespan and also 
      maintain neural differentiation, thus promoting the recovery of neurological 
      function following hypoxic-ischemic brain damage (HIBD) and thereby representing 
      a new effective strategy for HIBD in neonates.
CI  - Copyright (c) 2014. Published by Elsevier Ltd.
FAU - Zhao, Fengyan
AU  - Zhao F
AD  - Department of Pediatrics, West China Second University Hospital, Sichuan 
      University, Chengdu 610041, China; Key Laboratory of Obstetric & Gynecologic and 
      Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan 
      University, Chengdu 610041, China.
FAU - Qu, Yi
AU  - Qu Y
AD  - Department of Pediatrics, West China Second University Hospital, Sichuan 
      University, Chengdu 610041, China; Key Laboratory of Obstetric & Gynecologic and 
      Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan 
      University, Chengdu 610041, China.
FAU - Liu, Haiting
AU  - Liu H
AD  - Department of Pediatrics, West China Second University Hospital, Sichuan 
      University, Chengdu 610041, China; Key Laboratory of Obstetric & Gynecologic and 
      Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan 
      University, Chengdu 610041, China.
FAU - Du, Baowen
AU  - Du B
AD  - Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
FAU - Mu, Dezhi
AU  - Mu D
AD  - Department of Pediatrics, West China Second University Hospital, Sichuan 
      University, Chengdu 610041, China; Key Laboratory of Obstetric & Gynecologic and 
      Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan 
      University, Chengdu 610041, China; Department of Pediatrics and Neurology, 
      University of California, San Francisco, CA 94143, USA. Electronic address: 
      mudz@scu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140703
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.7.49 (Telomerase)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*therapeutic use
MH  - Humans
MH  - Hypoxia-Ischemia, Brain/*therapy
MH  - Infant, Newborn
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*physiology
MH  - Telomerase/*therapeutic use
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Hypoxic-ischemic brain damage
OT  - Telomerase reverse transcriptase
OT  - Umbilical cord blood mesenchymal stem cells
EDAT- 2014/07/08 06:00
MHDA- 2015/08/22 06:00
CRDT- 2014/07/08 06:00
PHST- 2014/05/23 00:00 [received]
PHST- 2014/06/18 00:00 [revised]
PHST- 2014/06/25 00:00 [accepted]
PHST- 2014/07/08 06:00 [entrez]
PHST- 2014/07/08 06:00 [pubmed]
PHST- 2015/08/22 06:00 [medline]
AID - S0736-5748(14)00096-3 [pii]
AID - 10.1016/j.ijdevneu.2014.06.014 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2014 Nov;38:147-54. doi: 10.1016/j.ijdevneu.2014.06.014. Epub 
      2014 Jul 3.