PMID- 24999309
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140707
LR  - 20211021
IS  - 1598-2629 (Print)
IS  - 2092-6685 (Electronic)
IS  - 1598-2629 (Linking)
VI  - 14
IP  - 3
DP  - 2014 Jun
TI  - Differential roles of lung dendritic cell subsets against respiratory virus 
      infection.
PG  - 128-37
LID - 10.4110/in.2014.14.3.128 [doi]
AB  - Respiratory viruses can induce acute respiratory disease. Clinical symptoms and 
      manifestations are dependent on interactions between the virus and host immune 
      system. Dendritic cells (DCs), along with alveolar macrophages, constitute the 
      first line of sentinel cells in the innate immune response against respiratory 
      viral infection. DCs play an essential role in regulating the immune response by 
      bridging innate and adaptive immunity. In the steady state, lung DCs can be 
      subdivided into CD103(+) conventional DCs (cDCs), CD11b(+) cDCs, and plasmacytoid 
      DCs (pDCs). In the inflammatory state, like a respiratory viral infection, 
      monocyte-derived DCs (moDCs) are recruited to the lung. In inflammatory lung, 
      discrimination between moDCs and CD11b(+) DCs in the inflamed lung has been a 
      critical challenge in understanding their role in the antiviral response. In 
      particular, CD103(+) cDCs migrate from the intraepithelial base to the draining 
      mediastinal lymph nodes to primarily induce the CD8(+) T cell response against 
      the invading virus. Lymphoid CD8alpha(+) cDCs, which have a developmental 
      relationship with CD103(+) cDCs, also play an important role in viral antigen 
      presentation. Moreover, pDCs have been reported to promote an antiviral response 
      by inducing type I interferon production rather than adaptive immunity. However, 
      the role of these cells in respiratory infections remains unclear. These 
      different DC subsets have functional specialization against respiratory viral 
      infection. Under certain viral infection, contextually controlling the balance of 
      these specialized DC subsets is important for an effective immune response and 
      maintenance of homeostasis.
FAU - Kim, Tae Hoon
AU  - Kim TH
AD  - Laboratory of Host Defenses, Graduate School of Medical Science and Engineering, 
      Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, 
      Korea.
FAU - Lee, Heung Kyu
AU  - Lee HK
AD  - Laboratory of Host Defenses, Graduate School of Medical Science and Engineering, 
      Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, 
      Korea.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140619
PL  - Korea (South)
TA  - Immune Netw
JT  - Immune network
JID - 101137270
PMC - PMC4079819
OTO - NOTNLM
OT  - Dendritic cells
OT  - Infection
OT  - Influenza
OT  - Lung
OT  - Respiratory syncytial virus
COIS- The authors have no financial conflict of interest.
EDAT- 2014/07/08 06:00
MHDA- 2014/07/08 06:01
PMCR- 2014/06/01
CRDT- 2014/07/08 06:00
PHST- 2014/04/29 00:00 [received]
PHST- 2014/05/22 00:00 [revised]
PHST- 2014/05/27 00:00 [accepted]
PHST- 2014/07/08 06:00 [entrez]
PHST- 2014/07/08 06:00 [pubmed]
PHST- 2014/07/08 06:01 [medline]
PHST- 2014/06/01 00:00 [pmc-release]
AID - 10.4110/in.2014.14.3.128 [doi]
PST - ppublish
SO  - Immune Netw. 2014 Jun;14(3):128-37. doi: 10.4110/in.2014.14.3.128. Epub 2014 Jun 
      19.