PMID- 24999311
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140707
LR  - 20211021
IS  - 1598-2629 (Print)
IS  - 2092-6685 (Electronic)
IS  - 1598-2629 (Linking)
VI  - 14
IP  - 3
DP  - 2014 Jun
TI  - Insulin resistance and serum levels of interleukin-17 and interleukin-18 in 
      normal pregnancy.
PG  - 149-55
LID - 10.4110/in.2014.14.3.149 [doi]
AB  - We performed this study to evaluate the role of Interleukin-17 (IL-17) and 
      Interleukin-18 (IL-18) in insulin resistance during normal pregnancy. This 
      descriptive cross sectional study was carried out on 97 healthy pregnant women 
      including 32, 25, and 40 individuals in the first, second, and third trimesters, 
      respectively, and on 28 healthy non pregnant women between the autumn of 2012 and 
      the spring of 2013. We analyzed the serum concentrations of IL-17 and IL-18 by 
      using the enzyme linked immunosorbent assay (ELISA). Insulin resistance was 
      measured by homeostasis model assessment of insulin resistance equation. No 
      significant differences between the demographic data of the pregnant and non 
      pregnant groups were observed. Insulin resistant in pregnant women was 
      significantly higher than the controls (p=0.006). Serum IL-17 concentration was 
      significantly different in non pregnant women and pregnant women in all 
      gestational ages (p<0.05). Serum IL-18 level was significantly lower in subjects 
      with first, second, and third trimesters of pregnancy in compared to non pregnant 
      women (p<0.05). No significant correlations were found between serum IL-17 and 
      IL-18 levels with insulin resistance (r=0.08, p=0.34 vs. r=0.01, p=0.91, 
      respectively). Our data suggested that IL-17 and IL-18 do not appear to attribute 
      greatly to pregnancy deduced insulin resistance during normal pregnancy.
FAU - Jahromi, Abdolreza Sotoodeh
AU  - Jahromi AS
AD  - Research Center for Cardiovascular Atherosclerosis, Jahrom University of Medical 
      Science, Jahrom, Iran. ; Department of Immunology, Jahrom University of Medical 
      Science, Jahrom, Iran.
FAU - Shojaei, Mohammad
AU  - Shojaei M
AD  - Research Center for Cardiovascular Atherosclerosis, Jahrom University of Medical 
      Science, Jahrom, Iran. ; Research Center for Social Determinants of Health, 
      Jahrom University of Medical Science, Jahrom, Iran.
FAU - Ghobadifar, Mohamed Amin
AU  - Ghobadifar MA
AD  - Department of Student Research Committee, Jahrom University of Medical Science, 
      Jahrom, Iran.
LA  - eng
PT  - Journal Article
DEP - 20140619
PL  - Korea (South)
TA  - Immune Netw
JT  - Immune network
JID - 101137270
PMC - PMC4079821
OTO - NOTNLM
OT  - Insulin resistance
OT  - Interleukin-17
OT  - Interleukin-18
OT  - Pregnancy
COIS- The authors have no financial conflict of interest.
EDAT- 2014/07/08 06:00
MHDA- 2014/07/08 06:01
PMCR- 2014/06/01
CRDT- 2014/07/08 06:00
PHST- 2014/04/03 00:00 [received]
PHST- 2014/05/05 00:00 [revised]
PHST- 2014/05/27 00:00 [accepted]
PHST- 2014/07/08 06:00 [entrez]
PHST- 2014/07/08 06:00 [pubmed]
PHST- 2014/07/08 06:01 [medline]
PHST- 2014/06/01 00:00 [pmc-release]
AID - 10.4110/in.2014.14.3.149 [doi]
PST - ppublish
SO  - Immune Netw. 2014 Jun;14(3):149-55. doi: 10.4110/in.2014.14.3.149. Epub 2014 Jun 
      19.