PMID- 24999831
OWN - NLM
STAT- MEDLINE
DCOM- 20150416
LR  - 20220410
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 48
DP  - 2014 Oct
TI  - Gender difference in association of cognition with BDNF in chronic schizophrenia.
PG  - 136-46
LID - S0306-4530(14)00211-X [pii]
LID - 10.1016/j.psyneuen.2014.06.004 [doi]
AB  - While numerous studies have reported that brain-derived neurotrophic factor 
      (BDNF) may be involved in the pathophysiology of schizophrenia, very few studies 
      have explored its association with cognitive impairment or gender differences in 
      schizophrenia which we explored. We compared gender differences in 248 chronic 
      schizophrenic patients (male/female=185/63) to 188 healthy controls 
      (male/female=98/90) on the Repeatable Battery for the Assessment of 
      Neuropsychological Status (RBANS) and serum BDNF. Schizophrenic symptoms were 
      assessed using the Positive and Negative Syndrome Scale (PANSS). Our results 
      showed that schizophrenic patients performed worse than normals on most of the 
      cognitive tasks, and male patients had significantly lower immediate memory and 
      delayed memory scores than female patients. BDNF levels were significantly lower 
      in patients than controls, and male patients had significantly lower BDNF levels 
      than female patients. For the patients, BDNF was positively associated with 
      immediate memory and the RBANS total score. Furthermore, these associations were 
      only observed in female not male patients. Among healthy controls, no gender 
      difference was observed in cognitive domains and BDNF levels, or in the 
      association between BDNF and cognition. Our results suggest gender differences in 
      cognitive impairments, BDNF levels and their association in chronic patients with 
      schizophrenia. However, the findings should be regarded as preliminary due to the 
      cross-sectional design and our chronic patients, which need replication in a 
      first-episode and drug naive patients using a longitudinal study.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Zhang, Xiang Yang
AU  - Zhang XY
AD  - Department of Psychiatry and Behavioral Sciences, Harris County Psychiatric 
      Center, The University of Texas Health Science Center at Houston, Houston, TX, 
      USA; Beijing HuiLongGuan Hospital, Peking University, Beijing, China. Electronic 
      address: zhangxy9@gmail.com.
FAU - Chen, Da-Chun
AU  - Chen DC
AD  - Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
FAU - Tan, Yun-Long
AU  - Tan YL
AD  - Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
FAU - Tan, Shu-Ping
AU  - Tan SP
AD  - Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
FAU - Wang, Zhi-Ren
AU  - Wang ZR
AD  - Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
FAU - Yang, Fu-De
AU  - Yang FD
AD  - Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
FAU - Xiu, Mei-Hong
AU  - Xiu MH
AD  - Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
FAU - Hui, Li
AU  - Hui L
AD  - Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
FAU - Lv, Meng-Han
AU  - Lv MH
AD  - Beijing HuiLongGuan Hospital, Peking University, Beijing, China.
FAU - Zunta-Soares, Giovana B
AU  - Zunta-Soares GB
AD  - Department of Psychiatry and Behavioral Sciences, Harris County Psychiatric 
      Center, The University of Texas Health Science Center at Houston, Houston, TX, 
      USA.
FAU - Soares, Jair C
AU  - Soares JC
AD  - Department of Psychiatry and Behavioral Sciences, Harris County Psychiatric 
      Center, The University of Texas Health Science Center at Houston, Houston, TX, 
      USA. Electronic address: jair.c.soares@uth.tmc.edu.
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140617
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Chronic Disease
MH  - Cognition/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Memory/physiology
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/*blood/*physiopathology
MH  - Sex Factors
OTO - NOTNLM
OT  - Association
OT  - BDNF
OT  - Cognition
OT  - Gender difference
OT  - Schizophrenia
EDAT- 2014/07/08 06:00
MHDA- 2015/04/17 06:00
CRDT- 2014/07/08 06:00
PHST- 2014/03/26 00:00 [received]
PHST- 2014/06/09 00:00 [revised]
PHST- 2014/06/09 00:00 [accepted]
PHST- 2014/07/08 06:00 [entrez]
PHST- 2014/07/08 06:00 [pubmed]
PHST- 2015/04/17 06:00 [medline]
AID - S0306-4530(14)00211-X [pii]
AID - 10.1016/j.psyneuen.2014.06.004 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2014 Oct;48:136-46. doi: 
      10.1016/j.psyneuen.2014.06.004. Epub 2014 Jun 17.