PMID- 2500084
OWN - NLM
STAT- MEDLINE
DCOM- 19890725
LR  - 20090213
IS  - 0003-9683 (Print)
IS  - 0003-9683 (Linking)
VI  - 82
IP  - 2
DP  - 1989 Feb
TI  - [Increased vasodilation response to the stimulation of low pressure 
      mechanoreceptors in borderline hypertension].
PG  - 231-5
AB  - Passive lifting of the lower limbs (antitilt) is a simple manoeuvre which 
      stimulates low-pressure mechanoreceptors. Patients with borderline hypertension 
      have an alteration of the arterial baroreflex modulated by an increased 
      inhibitory effect of cardiopulmonary mechanoreceptors on vasomotor centres. The 
      repercussions of antitilt on mean arterial pressure (MAP), heart rate (HR) and 
      blood flow rate in the forearm (FRFA) were studied in 30 male subjects aged 18 to 
      25 years: 14 with untreated borderline hypertension ("patients") and 16 controls. 
      FRFA was measured with a plethysmograph by means of a mercury constraint gauge. 
      MAP was recorded during exploration with a DINAMAP instrument. The parameters 
      were measured in recumbent position, then within minutes of the antitilt 
      manoeuvre. In recumbent position the differences between patients and controls 
      were: MAP 94.7 +/- 6 vs 84.7 +/- 7 mmHg (p less than 0.001); HR 76 +/- 13 vs 63 
      +/- 9 beats/min (p less than 0.01); FRFA 4.6 +/- 1.5 vs 3.5 +/- 1.4 ml/min/100 ml 
      (p less than 0.05). Following antitilt, MAP and HR remained unchanged in the two 
      groups, but there was a significant increase of FRFA in both controls (+ 0.6 +/- 
      0.2 ml/min/100 ml; p less than 0.02) and patients (+ 1.3 +/- 0.2 ml/min/100 ml; p 
      less than 0.001). This increase was significantly greater in patients than in 
      controls (p less than 0.05). This study shows that antitilt produces an increase 
      of blood flow rate in the forearm that is more pronounced in patients with 
      borderline hypertension than in controls. The stability of MAP and HR is in 
      favour of non-actuation of the high-pressure arterial baroreflex.(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Girerd, X
AU  - Girerd X
AD  - Centre de diagnostic, hopital Broussais, Paris.
FAU - Chanudet, X
AU  - Chanudet X
FAU - Clement, R
AU  - Clement R
FAU - Larroque, P
AU  - Larroque P
FAU - London, G
AU  - London G
FAU - Safar, M
AU  - Safar M
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Augmentation de la reponse vasodilatatrice a la stimulation des mecanorecepteurs 
      a basse pression chez l'hypertendu limite.
PL  - France
TA  - Arch Mal Coeur Vaiss
JT  - Archives des maladies du coeur et des vaisseaux
JID - 0406011
SB  - IM
MH  - Adult
MH  - Blood Flow Velocity
MH  - Blood Pressure
MH  - Forearm/blood supply
MH  - Heart Rate
MH  - Humans
MH  - Hypertension/*physiopathology
MH  - Male
MH  - Mechanoreceptors/*physiopathology
MH  - Posture
MH  - *Vasodilation
EDAT- 1989/02/01 00:00
MHDA- 1989/02/01 00:01
CRDT- 1989/02/01 00:00
PHST- 1989/02/01 00:00 [pubmed]
PHST- 1989/02/01 00:01 [medline]
PHST- 1989/02/01 00:00 [entrez]
PST - ppublish
SO  - Arch Mal Coeur Vaiss. 1989 Feb;82(2):231-5.