PMID- 25001019
OWN - NLM
STAT- MEDLINE
DCOM- 20160316
LR  - 20211203
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Print)
IS  - 1933-7191 (Linking)
VI  - 22
IP  - 1
DP  - 2015 Jan
TI  - Caloric restriction promotes the reserve of follicle pool in adult female rats by 
      inhibiting the activation of mammalian target of rapamycin signaling.
PG  - 60-7
LID - 10.1177/1933719114542016 [doi]
AB  - Caloric restriction (CR) is known to increase the number of primordial follicles 
      and prolong the reproductive life span. However, how CR modulates follicular 
      development is not well understood. In the present study, we examined the effects 
      of CR on follicular development in rats and investigated the underlying 
      mechanism. After 10 weeks of CR or high-fat diet, ovarian follicles at different 
      developmental stages were examined by histological analysis. Plasma levels of 
      luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estrogen (ESG) 
      were measured, and the levels of mammalian target of rapamycin (mTOR), p70S6 
      kinase (p70S6K), and phosphorylated p70S6K in the ovary were detected by Western 
      blot. The results showed that the reserve of follicle pool in CR rats was 
      increased, accompanied by decreased level of phosphorylated p70S6K in the ovary, 
      and decreased serum LH, FSH, and ESG levels. Taken together, these results 
      suggest that CR may suppress ovarian follicular development and enhance the 
      follicle pool reserve by inhibiting mTOR signaling.
CI  - (c) The Author(s) 2014.
FAU - Li, Li
AU  - Li L
AD  - Department of Gynaecology and Obstetrics of the First Affiliated Hospital, 
      Shantou University Medical College, Shantou, China.
FAU - Fu, Yu-cai
AU  - Fu YC
AD  - Laboratory of Cell Senescence, Shantou University Medical College, Shantou, 
      China.
FAU - Xu, Jin-jie
AU  - Xu JJ
AD  - Laboratory of Cell Senescence, Shantou University Medical College, Shantou, 
      China.
FAU - Lin, Xuan-hao
AU  - Lin XH
AD  - Department of Pathology of Shantou Central Hospital, Shantou, China.
FAU - Chen, Xiao-chun
AU  - Chen XC
AD  - Department of Gynaecology and Obstetrics of the First Affiliated Hospital, 
      Shantou University Medical College, Shantou, China.
FAU - Zhang, Xing-mei
AU  - Zhang XM
AD  - Department of Gynaecology and Obstetrics of HuiZhou Municipal Central Hospital, 
      Huizhou, China.
FAU - Luo, Li-li
AU  - Luo LL
AD  - Department of Gynaecology and Obstetrics of the First Affiliated Hospital, 
      Shantou University Medical College, Shantou, China luolili6606@163.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140706
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
RN  - 0 (Estrogens)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Body Weight
MH  - *Caloric Restriction
MH  - *Cell Proliferation
MH  - Diet, High-Fat
MH  - Estrogens/blood
MH  - Female
MH  - Follicle Stimulating Hormone/blood
MH  - Luteinizing Hormone/blood
MH  - Nutritional Status
MH  - Ovarian Follicle/*enzymology
MH  - Phosphorylation
MH  - Rats, Sprague-Dawley
MH  - Ribosomal Protein S6 Kinases, 70-kDa/metabolism
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Time Factors
PMC - PMC4275449
OTO - NOTNLM
OT  - caloric restriction
OT  - estrogen
OT  - luteinizing hormone
OT  - mTOR
OT  - primordial follicle
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2014/07/09 06:00
MHDA- 2016/03/17 06:00
PMCR- 2016/01/01
CRDT- 2014/07/09 06:00
PHST- 2014/07/09 06:00 [entrez]
PHST- 2014/07/09 06:00 [pubmed]
PHST- 2016/03/17 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 1933719114542016 [pii]
AID - 10.1177_1933719114542016 [pii]
AID - 10.1177/1933719114542016 [doi]
PST - ppublish
SO  - Reprod Sci. 2015 Jan;22(1):60-7. doi: 10.1177/1933719114542016. Epub 2014 Jul 6.