PMID- 25001952
OWN - NLM
STAT- MEDLINE
DCOM- 20150416
LR  - 20180816
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 47
DP  - 2014 Sep
TI  - Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism affects 
      sympathetic tone in a gender-specific way.
PG  - 17-25
LID - S0306-4530(14)00152-8 [pii]
LID - 10.1016/j.psyneuen.2014.04.019 [doi]
AB  - The Val/Val genotype of the brain-derived neurotrophic factor (BDNF) polymorphism 
      (Val66Met) has been reported to affect human anxiety-related phenotypes. 
      Substantial research has demonstrated that anxiety is associated with sympathetic 
      activation, while sex steroid hormones have been shown to exert differential 
      actions in regulating BDNF expression. Thus, we examined whether the BDNF variant 
      modulates autonomic function in a gender-dependent manner. From 708 adults 
      initially screened for medical and psychiatric illnesses, a final cohort of 583 
      drug-free healthy Han Chinese (355 males, 228 females; age 34.43+/-8.42 years) was 
      recruited for BDNF genotyping (Val/Val: 136, 23.3%, Val/Met: 294, 50.4%, and 
      Met/Met: 153, 26.2%). Time- and frequency-domain analyses of heart rate 
      variability (HRV) were used to assess autonomic outflow to the heart. Significant 
      genotype-by-gender interaction effects were found on HRV indices. Even after 
      adjusting for possible confounders, male participants bearing the Val/Val 
      genotype had significant increases in low frequency (LF), LF% and LF/high 
      frequency (HF) ratio, indicating altered sympathovagal balance with increased 
      sympathetic modulation, compared to male Met/Met homozygotes. Females, however, 
      showed an opposite but non-significant pattern. These results suggest that the 
      studied BDNF polymorphism is associated with sympathetic control in a 
      gender-specific way. The findings here support the view that male subjects with 
      the Val/Val genotype have increased risk of anxiety by association with 
      sympathetic activation.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Chang, Chuan-Chia
AU  - Chang CC
AD  - Department of Psychiatry, Tri-Service General Hospital, National Defense Medical 
      Center, Taipei, Taiwan; Graduate Institute of Medical Sciences, National Defense 
      Medical Center, Taipei, Taiwan.
FAU - Chang, Hsin-An
AU  - Chang HA
AD  - Department of Psychiatry, Tri-Service General Hospital, National Defense Medical 
      Center, Taipei, Taiwan.
FAU - Chen, Tien-Yu
AU  - Chen TY
AD  - Department of Psychiatry, Tri-Service General Hospital, National Defense Medical 
      Center, Taipei, Taiwan.
FAU - Fang, Wen-Hui
AU  - Fang WH
AD  - Department of Family and Community Medicine, Tri-Service General Hospital, 
      National Defense Medical Center, Taipei, Taiwan.
FAU - Huang, San-Yuan
AU  - Huang SY
AD  - Department of Psychiatry, Tri-Service General Hospital, National Defense Medical 
      Center, Taipei, Taiwan; Graduate Institute of Medical Sciences, National Defense 
      Medical Center, Taipei, Taiwan. Electronic address: hsy@ndmctsgh.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140502
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Amino Acid Substitution
MH  - Anxiety/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Heart Rate/*genetics
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Sympathetic Nervous System/*physiology
MH  - Valine/genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Autonomic nervous system (ANS)
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - Heart rate variability (HRV)
OT  - Polymorphism
OT  - Sympathetic control
EDAT- 2014/07/09 06:00
MHDA- 2015/04/17 06:00
CRDT- 2014/07/09 06:00
PHST- 2014/02/12 00:00 [received]
PHST- 2014/04/24 00:00 [revised]
PHST- 2014/04/25 00:00 [accepted]
PHST- 2014/07/09 06:00 [entrez]
PHST- 2014/07/09 06:00 [pubmed]
PHST- 2015/04/17 06:00 [medline]
AID - S0306-4530(14)00152-8 [pii]
AID - 10.1016/j.psyneuen.2014.04.019 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2014 Sep;47:17-25. doi: 10.1016/j.psyneuen.2014.04.019. 
      Epub 2014 May 2.