PMID- 25002134
OWN - NLM
STAT- MEDLINE
DCOM- 20150811
LR  - 20141216
IS  - 1752-8976 (Electronic)
IS  - 1470-3203 (Linking)
VI  - 15
IP  - 4
DP  - 2014 Dec
TI  - Brazilian embauba (Cecropia pachystachya) extract reduces renal lesions in 5/6 
      nephrectomized rats.
PG  - 430-9
LID - 10.1177/1470320313501219 [doi]
AB  - INTRODUCTION: Cecropia pachystachya (CP) is a plant rich in polyphenols which 
      inhibits the angiotensin-converting enzyme (ACE) in vitro. Angiotensin II (AII) 
      has an important role in the renal lesion provoked by 5/6 nephrectomy (NE). This 
      study evaluated the CP extract effect on renal lesions provoked by 5/6 NE. 
      MATERIALS AND METHODS: Male Wistar rats submitted to 5/6 NE were treated or not 
      treated with CP extract and followed for 90 days. Systemic blood pressure (SBP), 
      albuminuria, renal functional and structural parameters, ACE activity, urinary 
      levels of monocyte chemoattrant protein-1 (MCP-1) and transforming growth factor 
      beta (TGF-beta) were evaluated. RESULTS: Albuminuria and hypertension were less intense 
      in the treated (NE+CP) group compared to the untreated (NE) group. CP extract 
      treatment reduced the fall in glomerular filtration rate observed in NE rats. 
      Glomerulosclerosis, tubulointerstitial lesions, increase of macrophages and AII 
      positive cells in the renal cortex, as well as increases in renal ACE activity, 
      urinary levels of MCP-1 and TGF-beta were attenuated in NE rats by CP treatment. 
      CONCLUSIONS: The treatment with CP extract reduced the SBP and functional and 
      structural renal changes in 5/6 NE rats. These effects were associated with 
      decreased AII expression, ACE activity and inflammation in the renal cortex.
CI  - (c) The Author(s) 2014.
FAU - do C Maquiaveli, Claudia
AU  - do C Maquiaveli C
AD  - Department of Physiology, University of Sao Paulo, Brazil.
FAU - da Silva, Edson R
AU  - da Silva ER
AD  - Department of Veterinary Medicine, University of Sao Paulo, Brazil.
FAU - Francescato, Heloisa D C
AU  - Francescato HD
AD  - Department of Physiology, University of Sao Paulo, Brazil.
FAU - Costa, Roberto S
AU  - Costa RS
AD  - Department of Pathology, University of Sao Paulo, Brazil.
FAU - Silva, Cleonice G A
AU  - Silva CG
AD  - Department of Physiology, University of Sao Paulo, Brazil.
FAU - Casarini, Dulce E
AU  - Casarini DE
AD  - Department of Medicine, Federal University of Sao Paulo, Brazil.
FAU - Ronchi, Fernanda A
AU  - Ronchi FA
AD  - Department of Medicine, Federal University of Sao Paulo, Brazil.
FAU - Coimbra, Terezila M
AU  - Coimbra TM
AD  - Department of Physiology, University of Sao Paulo, Brazil tmcoimbr@fmrp.usp.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140707
PL  - England
TA  - J Renin Angiotensin Aldosterone Syst
JT  - Journal of the renin-angiotensin-aldosterone system : JRAAS
JID - 100971636
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Plant Extracts)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Albuminuria/pathology/urine
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Body Weight/drug effects
MH  - Brazil
MH  - Cecropia Plant/*chemistry
MH  - Chemokine CCL2/urine
MH  - Immunohistochemistry
MH  - Kidney/drug effects/*pathology/physiopathology/*surgery
MH  - Kidney Function Tests
MH  - Male
MH  - *Nephrectomy
MH  - Osmolar Concentration
MH  - Plant Extracts/*pharmacology
MH  - Rats, Wistar
MH  - Systole/drug effects
MH  - Transforming Growth Factor beta/urine
OTO - NOTNLM
OT  - Cecropia pachystachya
OT  - angiotensin II
OT  - inflammation
OT  - renal failure
EDAT- 2014/07/09 06:00
MHDA- 2015/08/12 06:00
CRDT- 2014/07/09 06:00
PHST- 2014/07/09 06:00 [entrez]
PHST- 2014/07/09 06:00 [pubmed]
PHST- 2015/08/12 06:00 [medline]
AID - 1470320313501219 [pii]
AID - 10.1177/1470320313501219 [doi]
PST - ppublish
SO  - J Renin Angiotensin Aldosterone Syst. 2014 Dec;15(4):430-9. doi: 
      10.1177/1470320313501219. Epub 2014 Jul 7.