PMID- 25002368
OWN - NLM
STAT- MEDLINE
DCOM- 20150612
LR  - 20181202
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 126
IP  - 2
DP  - 2015 Feb
TI  - Does the region of epileptogenicity influence the pattern of change in cortical 
      excitability?
PG  - 249-56
LID - S1388-2457(14)00305-8 [pii]
LID - 10.1016/j.clinph.2014.05.029 [doi]
AB  - OBJECTIVE: To investigate whether cortical excitability measures on transcranial 
      magnetic stimulation (TMS) differed between groups of patients with different 
      focal epilepsy syndromes. METHODS: 85 Patients with focal epilepsy syndromes 
      divided into temporal and extra-temporal lobe epilepsy were studied. The cohorts 
      were further divided into drug naive-new onset, refractory and seizure free 
      groups. Motor threshold (MT) and paired pulse TMS at short (2, 5, 10, 15 ms) and 
      long (100-300 ms) interstimulus intervals (ISIs) were measured. Results were 
      compared to those of 20 controls. RESULTS: Cortical excitability was higher at 2 
      & 5 ms and 250, 300 ms ISIs (p<0.01) in focal epilepsy syndromes compared to 
      controls however significant inter-hemispheric differences in MT and the same 
      ISIs were only seen in the drug naive state early at onset and were much more 
      prominent in temporal lobe epilepsy. CONCLUSION: Disturbances in cortical 
      excitability are more confined to the affected hemisphere in temporal lobe 
      epilepsy but only early at onset in the drug naive state. SIGNIFICANCE: Group TMS 
      studies show that cortical excitability measures are different in temporal lobe 
      epilepsy and can be distinguished from other focal epilepsies early at onset in 
      the drug naive state. Further studies are needed to determine whether these 
      results can be applied clinically as the utility of TMS in distinguishing between 
      epilepsy syndromes at an individual level remains to be determined.
CI  - Copyright (c) 2014 International Federation of Clinical Neurophysiology. Published 
      by Elsevier Ireland Ltd. All rights reserved.
FAU - Badawy, Radwa A B
AU  - Badawy RA
AD  - Department of Clinical Neurosciences, St Vincent's Hospital, Fitzroy, Australia; 
      Department of Medicine, The University of Melbourne, Parkville, Australia; 
      Department of Electrical and Electronic Engineering, The University of Melbourne, 
      Parkville, Australia. Electronic address: badawyr@unimelb.edu.au.
FAU - Vogrin, Simon J
AU  - Vogrin SJ
AD  - Department of Clinical Neurosciences, St Vincent's Hospital, Fitzroy, Australia.
FAU - Lai, Alan
AU  - Lai A
AD  - Bionics Institute, East Melbourne, Victoria, Australia.
FAU - Cook, Mark J
AU  - Cook MJ
AD  - Department of Clinical Neurosciences, St Vincent's Hospital, Fitzroy, Australia; 
      Department of Medicine, The University of Melbourne, Parkville, Australia.
LA  - eng
PT  - Journal Article
DEP - 20140618
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cohort Studies
MH  - Epilepsies, Partial/diagnosis/physiopathology
MH  - Epilepsy, Temporal Lobe/*diagnosis/*physiopathology
MH  - Evoked Potentials, Motor/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Cortex/*physiopathology
MH  - Transcranial Magnetic Stimulation/*methods
MH  - Young Adult
OTO - NOTNLM
OT  - Cortical excitability
OT  - Focal epilepsy syndromes
OT  - Seizures
OT  - Transcranial magnetic stimulation
EDAT- 2014/07/09 06:00
MHDA- 2015/06/13 06:00
CRDT- 2014/07/09 06:00
PHST- 2014/01/25 00:00 [received]
PHST- 2014/05/11 00:00 [revised]
PHST- 2014/05/14 00:00 [accepted]
PHST- 2014/07/09 06:00 [entrez]
PHST- 2014/07/09 06:00 [pubmed]
PHST- 2015/06/13 06:00 [medline]
AID - S1388-2457(14)00305-8 [pii]
AID - 10.1016/j.clinph.2014.05.029 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2015 Feb;126(2):249-56. doi: 10.1016/j.clinph.2014.05.029. 
      Epub 2014 Jun 18.