PMID- 25003088
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140708
LR  - 20211021
IS  - 2287-3651 (Print)
IS  - 2287-366X (Electronic)
IS  - 2287-3651 (Linking)
VI  - 3
IP  - 2
DP  - 2014 Jul
TI  - Vaccine strategies utilizing C-type lectin receptors on dendritic cells in vivo.
PG  - 149-54
LID - 10.7774/cevr.2014.3.2.149 [doi]
AB  - Dendritic cells (DCs) are professional antigen-presenting cells capable of 
      initiating and regulating innate and adaptive immunity. The development of 
      effective ways to produce a large number of DCs in laboratories made the use of 
      DCs available in various vaccine approaches. Compared to conventional vaccines, 
      focused on protective antibody responses, DC vaccines emphasize protective T cell 
      immunity but might elicit strong antibody responses as well. In addition, the 
      recent discoveries of functionally distinct DC subsets in various organs and 
      tissues are likely to increase the potential of exploiting DCs in vaccines and 
      immunotherapy. Vaccines composed of DCs generated ex vivo, pulsed with antigens, 
      and matured prior to being re-infused to the body have been widely tried 
      clinically but resulted in limited success due to various obstacles. In this 
      review, new approaches that protein vaccines are selectively targeted to the 
      endocytic C-type lectin receptors on surface of DCs in vivo are discussed.
FAU - Park, Chae Gyu
AU  - Park CG
AUID- ORCID: 0000-0003-1906-1308
AD  - Laboratory of Immunology, Severance Biomedical Science Institute, Brain 21 PLUS 
      project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
LA  - eng
GR  - R21 AI093216/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20140620
PL  - Korea (South)
TA  - Clin Exp Vaccine Res
JT  - Clinical and experimental vaccine research
JID - 101592344
PMC - PMC4083067
OTO - NOTNLM
OT  - Antigen receptor
OT  - C-type lectins
OT  - Dendritic cells
OT  - Monoclonal antibody
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2014/07/09 06:00
MHDA- 2014/07/09 06:01
PMCR- 2014/07/01
CRDT- 2014/07/09 06:00
PHST- 2014/02/08 00:00 [received]
PHST- 2014/03/26 00:00 [revised]
PHST- 2014/03/30 00:00 [accepted]
PHST- 2014/07/09 06:00 [entrez]
PHST- 2014/07/09 06:00 [pubmed]
PHST- 2014/07/09 06:01 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - 10.7774/cevr.2014.3.2.149 [doi]
PST - ppublish
SO  - Clin Exp Vaccine Res. 2014 Jul;3(2):149-54. doi: 10.7774/cevr.2014.3.2.149. Epub 
      2014 Jun 20.