PMID- 25003674
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20150518
IS  - 2148-5607 (Electronic)
IS  - 1300-4948 (Linking)
VI  - 25
IP  - 2
DP  - 2014 Apr
TI  - Peptic ulcer complications requiring surgery: what has changed in the last 50 
      years in Turkey.
PG  - 152-5
LID - 10.5152/tjg.2014.5526 [doi]
AB  - BACKGROUND/AIMS: The incidence and prevalence of peptic ulcer disease has 
      decreased in recent years, but it is not so easy to make the same conclusion when 
      complications of peptic ulcer are taken into consideration. The aim of this study 
      is to determine the time trends in complicated peptic ulcer disease and to state 
      the effects of H2 receptor blockers, proton pump inhibitors (PPI), and H. pylori 
      eradication therapies on these complications. MATERIALS AND METHODS: This study 
      retrospectively evaluated the patients who were operated on for complications 
      (perforation, bleeding, and obstruction) of peptic ulcer for the last 50 years. 
      Patients were grouped into four groups (G1-G4) according to the dates in which H2 
      receptor blockers, PPIs, and eradication regimens for H. pylori were introduced 
      The time periods that were studied were: (G1) 1962-1980, (G2) 1981-1990, (G3) 
      1991-1997, and (G4) 1998-2012. RESULTS: In total, 2953 patients were operated on 
      for complications of peptic ulcer disease, of which 86% of the patients were 
      male. In G1, perforation and obstruction were significantly the most frequent 
      complications (p<0.001), followed by bleeding. In groups G2 and G3, obstruction 
      was still the most frequent complication requiring surgery (p<0.001). In G2 and 
      G3, obstruction was followed by perforation and bleeding, respectively. In G4, 
      perforation was significantly the most frequent complication (p<0.001). 
      CONCLUSION: From 1962 to 1990 obstruction was the most common complication 
      requiring surgery. In the last decade, perforation became the most common 
      complication. In contrast to reports in the literature, bleeding was the least 
      common complication requiring surgery in Turkey.
FAU - Guzel, Hakan
AU  - Guzel H
AD  - Department of General Surgery, Diskapi Yildirim Beyazit Teaching and 
      ResearchHospital, Ankara, Turkey. hakanguzel@gmail.com.
FAU - Kahramanca, Sahin
AU  - Kahramanca S
FAU - Seker, Duray
AU  - Seker D
FAU - Ozgehan, Gulay
AU  - Ozgehan G
FAU - Tunc, Gunduz
AU  - Tunc G
FAU - Kucukpinar, Tevfik
AU  - Kucukpinar T
FAU - Kargici, Hulagu
AU  - Kargici H
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Turk J Gastroenterol
JT  - The Turkish journal of gastroenterology : the official journal of Turkish Society 
      of Gastroenterology
JID - 9515841
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Female
MH  - Helicobacter Infections/complications/drug therapy
MH  - Histamine H2 Antagonists/therapeutic use
MH  - Humans
MH  - Incidence
MH  - Intestinal Obstruction/*epidemiology/etiology/surgery
MH  - Male
MH  - Middle Aged
MH  - Peptic Ulcer/*complications/drug therapy/surgery
MH  - Peptic Ulcer Hemorrhage/*epidemiology/surgery
MH  - Peptic Ulcer Perforation/*epidemiology/surgery
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Retrospective Studies
MH  - Turkey/epidemiology
MH  - Young Adult
EDAT- 2014/07/09 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/07/09 06:00
PHST- 2014/07/09 06:00 [entrez]
PHST- 2014/07/09 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - 10.5152/tjg.2014.5526 [doi]
PST - ppublish
SO  - Turk J Gastroenterol. 2014 Apr;25(2):152-5. doi: 10.5152/tjg.2014.5526.