PMID- 25005881
OWN - NLM
STAT- MEDLINE
DCOM- 20150312
LR  - 20220410
IS  - 1744-8069 (Electronic)
IS  - 1744-8069 (Linking)
VI  - 10
DP  - 2014 Jul 8
TI  - Higher serum S100B and BDNF levels are correlated with a lower pressure-pain 
      threshold in fibromyalgia.
PG  - 46
LID - 10.1186/1744-8069-10-46 [doi]
AB  - BACKGROUND: Fibromyalgia (FM) is conceptualized as a central sensitization (CS) 
      condition, that presents high serum brain-derived neurotrophic factor (BDNF) and 
      neuroglia activation. Although the S100B protein regulates neuroglia functions, 
      it has been traditionally used as a proxy of central nervous system damage. 
      However, neither BDNF nor S100B association with the clinical picture of FM has 
      been elucidated. To explore their association with the pressure-pain threshold 
      (PPT) in FM, we performed a cross-sectional study, including 56 females with 
      confirmed FM aged 18-65 years. Linear regression models were used to adjust for 
      potential confounding factors between serum BDNF, S100B and PPT. RESULTS: Serum 
      BDNF and S100B were correlated (Spearman's Rho = 0.29). Serum BDNF (log) and 
      S100B (log) were correlated with the PPT (log) (Partial eta2 = 0.129, P = 0.012 for 
      the BDNF (log), and Partial eta2 = 0.105, P = 0.025 for the S100B (log)). Serum 
      BDNF (log) was inversely associated with PPT (log) (beta = -1.01, SE = 0.41), age 
      (beta = -0.02, SE = 0.15) and obsessive compulsive disorder (beta = -0.36, SE = 0.15), 
      while serum S100B (log) was inversely associated with PPT (log) (beta = -1.38, 
      SE = 0.50), only. CONCLUSIONS: Both neuroglia key mediators in the CS process 
      were inversely correlated with the PPT. Serum assessment of BDNF and S100B 
      deserve further study to determine its potential as a proxy for the CS spectrum 
      in FM.
FAU - Zanette, Simone Azevedo
AU  - Zanette SA
FAU - Dussan-Sarria, Jairo Alberto
AU  - Dussan-Sarria JA
FAU - Souza, Andressa
AU  - Souza A
FAU - Deitos, Alicia
AU  - Deitos A
FAU - Torres, Iraci Lucena Silva
AU  - Torres IL
FAU - Caumo, Wolnei
AU  - Caumo W
AD  - Post Graduate Program in Medical Sciences, UFRGS, Porto Alegre, Brazil. 
      caumo@cpovo.net.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140708
PL  - United States
TA  - Mol Pain
JT  - Molecular pain
JID - 101242662
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (S100 Calcium Binding Protein beta Subunit)
RN  - 0 (S100B protein, human)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fibromyalgia/*blood/*physiopathology
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Pain Threshold/*physiology
MH  - Pressure/*adverse effects
MH  - Retrospective Studies
MH  - S100 Calcium Binding Protein beta Subunit/*blood
PMC - PMC4094546
EDAT- 2014/07/10 06:00
MHDA- 2015/03/13 06:00
PMCR- 2014/07/08
CRDT- 2014/07/10 06:00
PHST- 2014/03/10 00:00 [received]
PHST- 2014/07/03 00:00 [accepted]
PHST- 2014/07/10 06:00 [entrez]
PHST- 2014/07/10 06:00 [pubmed]
PHST- 2015/03/13 06:00 [medline]
PHST- 2014/07/08 00:00 [pmc-release]
AID - 1744-8069-10-46 [pii]
AID - 10.1186/1744-8069-10-46 [doi]
PST - epublish
SO  - Mol Pain. 2014 Jul 8;10:46. doi: 10.1186/1744-8069-10-46.