PMID- 25006296
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140709
LR  - 20211021
IS  - 0971-5851 (Print)
IS  - 0975-2129 (Electronic)
IS  - 0971-5851 (Linking)
VI  - 35
IP  - 1
DP  - 2014 Jan
TI  - Metastatic perivascular epithelioid cell tumor responding to mammalian target of 
      rapamycin inhibition.
PG  - 99-102
LID - 10.4103/0971-5851.133733 [doi]
AB  - Perivascular epithelioid cell tumors (PEComa) are a family of rare mesenchymal 
      tumors composed of histologically and immunohistochemically distinctive 
      perivascular epithelioid cells. Female genital tract and retroperitoneum are 
      common sites of origin of PEComa-not otherwise specified. Diagnosis depends upon 
      characteristic morphology and immunohistochemistry findings. Prognosis of 
      unresectable or metastatic disease is poor. Responses to mammalian target of 
      rapamycin (mTOR) inhibition are encouraging but mostly short-lived. We report a 
      case of metastatic PEComa who responded to mTOR inhibition, albeit for a short 
      duration. We also review the existing literature on mTOR inhibitors in PEComa.
FAU - Ghosh, Indranil
AU  - Ghosh I
AD  - Department of Medical Oncology, Tata Medical Center, Kolkata, West Bengal, India.
FAU - Arun, Indu
AU  - Arun I
AD  - Department of Pathology, Tata Medical Center, Kolkata, West Bengal, India.
FAU - Sen, Saugata
AU  - Sen S
AD  - Department of Radiodiagnosis, Tata Medical Center, Kolkata, West Bengal, India.
FAU - Mishra, Lopamudra
AU  - Mishra L
AD  - Department of Medical Oncology, Tata Medical Center, Kolkata, West Bengal, India.
LA  - eng
PT  - Case Reports
PL  - Germany
TA  - Indian J Med Paediatr Oncol
JT  - Indian journal of medical and paediatric oncology : official journal of Indian 
      Society of Medical & Paediatric Oncology
JID - 9604571
PMC - PMC4080675
OTO - NOTNLM
OT  - Immunohistochemistry
OT  - mammalian target of rapamycin inhibitors
OT  - perivascular epithelioid cell tumors
OT  - temsirolimus
COIS- Conflict of Interest: None declared.
EDAT- 2014/07/10 06:00
MHDA- 2014/07/10 06:01
PMCR- 2014/01/01
CRDT- 2014/07/10 06:00
PHST- 2014/07/10 06:00 [entrez]
PHST- 2014/07/10 06:00 [pubmed]
PHST- 2014/07/10 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - IJMPO-35-99 [pii]
AID - 10.4103/0971-5851.133733 [doi]
PST - ppublish
SO  - Indian J Med Paediatr Oncol. 2014 Jan;35(1):99-102. doi: 
      10.4103/0971-5851.133733.