PMID- 25007029
OWN - NLM
STAT- MEDLINE
DCOM- 20150911
LR  - 20181202
IS  - 1557-7465 (Electronic)
IS  - 1079-9907 (Linking)
VI  - 35
IP  - 1
DP  - 2015 Jan
TI  - Upregulated interleukin-21 receptor on B cells associated with the downregulation 
      of IgE in patients with allergic rhinitis.
PG  - 42-8
LID - 10.1089/jir.2014.0036 [doi]
AB  - Allergic diseases, such as allergic rhinitis, caused by an immunoglobulin E 
      (IgE)-mediated reaction to specific allergens are a common chronic condition 
      worldwide. Interleukin-21 (IL-21), a type I cytokine that is produced by T cells, 
      exerts regulatory effects on a variety of immune cells. In our previous study, we 
      found that serum levels of IL-21 were significantly decreased in patients with 
      severe atopic dermatitis, suggesting that IL-21 might play a role in allergic 
      reactions. In this study, we investigated the role of IL-21/IL-21 receptor 
      (IL-21R) in patients with allergic rhinitis. Our results demonstrated that there 
      was no difference in IL-21 serum levels between allergic rhinitis patients and 
      controls. However, allergic patients had significantly increased expression of 
      IL-21R on naive and memory B cells. IL-21R was upregulated through stimulation by 
      the combination of CD40 ligand (CD40L) and IL-4. IL-21 alone neither induced nor 
      inhibited IgE secretion from CD40L-stimulated B cells. However, IL-21 inhibited 
      IgE secretion of B cells that were induced by the combination of CD40L and IL-4 
      in allergic patients. Moreover, a negative correlation between the expression of 
      IL-21R and serum levels of IgE was found in patients with allergy. These results 
      suggest that the role of IL-21 in an ongoing allergic reaction is to downregulate 
      the IgE level by binding to IL-21R on B cells, which increases the expression in 
      allergic patients.
FAU - Jen, Hsiao-Yu
AU  - Jen HY
AD  - 1 Department of Clinical Laboratory Sciences and Medical Biotechnology, College 
      of Medicine, National Taiwan University , Taipei, Taiwan .
FAU - Yang, Yao-Hsu
AU  - Yang YH
FAU - Chiang, Bor-Luen
AU  - Chiang BL
FAU - Chuang, Ya-Hui
AU  - Chuang YH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140709
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (IL21R protein, human)
RN  - 0 (Interleukin-21 Receptor alpha Subunit)
RN  - 0 (Interleukins)
RN  - 147205-72-9 (CD40 Ligand)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 1.4.3.2 (IL4I1 protein, human)
RN  - EC 1.4.3.2 (L-Amino Acid Oxidase)
RN  - MKM3CA6LT1 (interleukin-21)
SB  - IM
MH  - Adult
MH  - B-Lymphocytes/*immunology
MH  - CD40 Ligand/immunology
MH  - Down-Regulation
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis/blood/immunology
MH  - Interleukin-21 Receptor alpha Subunit/*biosynthesis/immunology
MH  - Interleukins/blood/*immunology/metabolism
MH  - L-Amino Acid Oxidase/immunology
MH  - Male
MH  - Protein Binding
MH  - Rhinitis, Allergic/*immunology
MH  - Up-Regulation
MH  - Young Adult
EDAT- 2014/07/10 06:00
MHDA- 2015/09/12 06:00
CRDT- 2014/07/10 06:00
PHST- 2014/07/10 06:00 [entrez]
PHST- 2014/07/10 06:00 [pubmed]
PHST- 2015/09/12 06:00 [medline]
AID - 10.1089/jir.2014.0036 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 2015 Jan;35(1):42-8. doi: 10.1089/jir.2014.0036. Epub 
      2014 Jul 9.