PMID- 25007776
OWN - NLM
STAT- MEDLINE
DCOM- 20151201
LR  - 20211021
IS  - 1573-7373 (Electronic)
IS  - 0167-594X (Linking)
VI  - 120
IP  - 1
DP  - 2014 Oct
TI  - Polysomy of chromosomes 1 and 19: an underestimated prognostic factor in 
      oligodendroglial tumors.
PG  - 131-8
LID - 10.1007/s11060-014-1526-y [doi]
AB  - The clinical significance of chromosomes 1 and 19 deletion was well established 
      in oligodendroglial tumors (ODGs). This study was designed to evaluate the 
      prognostic implication of chromosomes 1 and 19 polysomy in gliomas. 584 patients 
      with histological diagnosis of primary gliomas enrolled in the study. Chromosomes 
      1 and 19 status was detected with fluorescence in situ hybridization (FISH). Of 
      the 584 cases, the frequency of 1q and 19p polysomy in mixed gliomas was 
      significantly higher than ODGs or astrocytic tumors (1q P = 0.032 and P = 0.044; 
      19p P = 0.024 and P = 0.027); the frequency of 1q and 19p polysomy in low-grade 
      gliomas (WHO II) was relatively lower compared with WHO III or WHO IV (1q P = 
      0.097 and P = 0.026; 19p P = 0.04 and P = 0.002). 1q, 19p and co-polysomy were 
      confirmed as risk factors conveyed unfavorable outcomes, which has been further 
      validated in both anaplastic oligodendroglial tumors (AOGs) (P = 0.07, P = 0.028 
      and P = 0.054 for PFS; P = 0.007, P = 0.001 and P = 0.002 for OS, respectively) 
      and glioblastomas with oligodendroglioma component (GBMOs) (P = 0.005, P < 0.001 
      and P < 0.001 for PFS; P = 0.136, P = 0.006 and P = 0.051 for OS, respectively). 
      Based on chromosomes 1/19 co-deletion and co-polysomy, AOGs and GBMOs could be 
      divided into three subgroups which harbored distinct prognosis (AOGs P < 0.001 
      for PFS and P < 0.001 for OS; GBMOs P < 0.001 for PFS and P = 0.012 for OS). 
      Chromosomes 1/19 polysomy are potential prognostic factors which confer 
      unfavorable outcomes. The molecular prognostic grouping model based on 
      chromosomes 1/19 co-polysomy and co-deletion better predicts prognosis and 
      provides a more reliable information for treatment decision-making.
FAU - Jiang, Haihui
AU  - Jiang H
AD  - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 
      China National Clinical Research Center for Neurological Diseases, Center of 
      Brain Tumor, Beijing Institute for Brain Disorders and Beijing Key Laboratory of 
      Brain Tumor, Beijing, 100050, People's Republic of China.
FAU - Ren, Xiaohui
AU  - Ren X
FAU - Zhang, Zhe
AU  - Zhang Z
FAU - Zeng, Wei
AU  - Zeng W
FAU - Wang, Junmei
AU  - Wang J
FAU - Lin, Song
AU  - Lin S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140710
PL  - United States
TA  - J Neurooncol
JT  - Journal of neuro-oncology
JID - 8309335
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Brain Neoplasms/*genetics/mortality/pathology/therapy
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Chromosomes, Human, Pair 19/*genetics
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Oligodendroglioma/*genetics/mortality/pathology/therapy
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Young Adult
EDAT- 2014/07/11 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/07/11 06:00
PHST- 2014/01/09 00:00 [received]
PHST- 2014/06/28 00:00 [accepted]
PHST- 2014/07/11 06:00 [entrez]
PHST- 2014/07/11 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1007/s11060-014-1526-y [doi]
PST - ppublish
SO  - J Neurooncol. 2014 Oct;120(1):131-8. doi: 10.1007/s11060-014-1526-y. Epub 2014 
      Jul 10.