PMID- 25008067
OWN - NLM
STAT- MEDLINE
DCOM- 20150514
LR  - 20221207
IS  - 1559-131X (Electronic)
IS  - 1357-0560 (Linking)
VI  - 31
IP  - 8
DP  - 2014 Aug
TI  - 11q23 abnormalities in adult Chinese patients with hematological malignancies.
PG  - 115
LID - 10.1007/s12032-014-0115-4 [doi]
AB  - The mixed lineage leukemia (MLL) gene on chromosome region 11q23 is frequently 
      involved in chromosomal translocations associated with various human hematologic 
      malignant neoplasms. The aim of this study was to investigate the profile of 
      11q23 abnormalities in adult Chinese patients with hematological malignancies. In 
      this study, 11q23 abnormalities were detected by cytogenetic and fluorescence in 
      situ hybridization (FISH) approaches in 77 out of a total of 2,404 adult Chinese 
      patients with leukemia, lymphoma, and myelodysplastic syndrome (MDS). 11q23 
      abnormalities were found in 5.31 % of the acute myeloid leukemia (AML) cases, 
      5.71 % of the acute lymphoid leukemia (ALL) cases, 2.94 % of lymphoma cases, and 
      1.24 % of MDS cases. Of the patients with 11q23 abnormalities, 59.74 % showed 
      rearrangement or deletion of the MLL gene by FISH; a novel 11q23 rearrangement, 
      der(6)t(6;11)(q23;q23), was discovered in one case. Our data showed that 
      t(11;19)(q23;p13.1) was the most frequent translocation in AML patients and 
      t(4;11)(q21;q23) was the most frequent translocation in ALL patients. FLT-ITD 
      mutations were detected in three out of 33 AML patients with 11q23 abnormalities 
      (9.09 %). The Kaplan-Meier survival analysis further showed that the 11q23 
      aberration was a poor prognostic factor for AML. The median survival times in the 
      11q23 aberration subgroup, the normal karyotype subgroup, and the subgroup with 
      other abnormalities were 7.4, 11.3, and 16.8 months, respectively (P = 0.0464). 
      Our study found one novel 11q23 rearrangement, der(6)t(6;11)(q23;q23), and 
      demonstrated the profile of 11q23 abnormalities in adult Chinese patients with 
      hematological malignancies.
FAU - Zhao, Xiaoli
AU  - Zhao X
AD  - Department of Hematology, Huashan Hospital, Fudan University, 12 Wulumuqi Road 
      Central, Shanghai, 200040, China.
FAU - Li, Shuang
AU  - Li S
FAU - Li, Nianyi
AU  - Li N
FAU - Fan, Rong
AU  - Fan R
FAU - Lin, Guowei
AU  - Lin G
FAU - Wang, Xiaoqin
AU  - Wang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140710
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/genetics
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 11
MH  - Female
MH  - Hematologic Neoplasms/*genetics/mortality
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia/genetics
MH  - Leukemia, Myeloid, Acute/genetics/mortality
MH  - Lymphoma/genetics/mortality
MH  - Male
MH  - Middle Aged
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics/mortality
MH  - Translocation, Genetic
MH  - Young Adult
EDAT- 2014/07/11 06:00
MHDA- 2015/05/15 06:00
CRDT- 2014/07/11 06:00
PHST- 2014/06/27 00:00 [received]
PHST- 2014/07/01 00:00 [accepted]
PHST- 2014/07/11 06:00 [entrez]
PHST- 2014/07/11 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
AID - 10.1007/s12032-014-0115-4 [doi]
PST - ppublish
SO  - Med Oncol. 2014 Aug;31(8):115. doi: 10.1007/s12032-014-0115-4. Epub 2014 Jul 10.