PMID- 25008451
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20140728
IS  - 1205-7541 (Electronic)
IS  - 0008-4212 (Linking)
VI  - 92
IP  - 8
DP  - 2014 Aug
TI  - Simulated microgravity induces an inflammatory response in the common carotid 
      artery of rats.
PG  - 661-8
LID - 10.1139/cjpp-2014-0066 [doi]
AB  - Post-spaceflight orthostatic intolerance is one of the most important adverse 
      effects after exposure to space microgravity, and there are still no effective 
      countermeasures. It has been considered that arterial remodeling may play an 
      important role in the occurrence of post-spaceflight orthostatic intolerance, but 
      the cellular mechanisms remain unknown. In this study, we investigated whether an 
      inflammatory response exists in the common carotid artery of rats exposed to 
      simulated microgravity. For this, Sprague-Dawley rats were subjected to 4 weeks 
      of hindlimb unweighting to simulate microgravity. The expression levels of the 
      adhesion molecules E-selectin and vascular cell adhesion molecule-1 (VCAM-1), and 
      the cytokine monocyte chemoattractant protein-1 (MCP-1) in the common carotid 
      artery of simulated microgravity rats were evaluated by immunohistochemical 
      staining, quantitative RT-PCR, and Western blot analyses. The recruitment of 
      monocytes in the common carotid artery of rats exposed to simulated microgravity 
      was investigated by en face immunofluorescence staining and monocyte binding 
      assays. Our results provided convincing evidence that there is an inflammatory 
      response in the common carotid artery of rats exposed to simulated microgravity. 
      Our work suggests that the inflammatory response may be a novel cellular 
      mechanism that is responsible for the arterial remodeling that occurs during 
      exposure to microgravity.
FAU - Liu, Huan
AU  - Liu H
AD  - a Department of Aerospace Physiology, Key Laboratory of Aerospace Medicine of 
      Ministry of Education, Fourth Military Medical University, 169 Changle West Road, 
      Xi'an 710032, Shaanxi Province, China.
FAU - Wang, Zhong-Chao
AU  - Wang ZC
FAU - Yue, Yuan
AU  - Yue Y
FAU - Yu, Jin-Wen
AU  - Yu JW
FAU - Cai, Yue
AU  - Cai Y
FAU - Bai, Yun-Gang
AU  - Bai YG
FAU - Zhang, Hai-Jun
AU  - Zhang HJ
FAU - Bao, Jun-Xiang
AU  - Bao JX
FAU - Ren, Xin-Ling
AU  - Ren XL
FAU - Xie, Man-Jiang
AU  - Xie MJ
FAU - Ma, Jin
AU  - Ma J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140606
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 0 (Chemokine CCL2)
RN  - 0 (E-Selectin)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - Carotid Artery Diseases/etiology/*metabolism/pathology
MH  - Carotid Artery, Common/*metabolism/pathology
MH  - Chemokine CCL2/genetics/metabolism
MH  - E-Selectin/genetics/metabolism
MH  - Endothelium, Vascular/metabolism
MH  - Hindlimb Suspension/*adverse effects
MH  - Inflammation/etiology/metabolism/pathology
MH  - Male
MH  - Monocytes/metabolism
MH  - Rats, Sprague-Dawley
MH  - Vascular Cell Adhesion Molecule-1/genetics/metabolism
MH  - Vascular Remodeling
OTO - NOTNLM
OT  - allegement des membres posterieurs
OT  - arterial remodeling
OT  - artere carotide commune
OT  - common carotid artery
OT  - hindlimb unweighted
OT  - inflammatory response
OT  - microgravite simulee
OT  - remodelage arteriel
OT  - reponse inflammatoire
OT  - simulated microgravity
EDAT- 2014/07/11 06:00
MHDA- 2015/05/12 06:00
CRDT- 2014/07/11 06:00
PHST- 2014/07/11 06:00 [entrez]
PHST- 2014/07/11 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
AID - 10.1139/cjpp-2014-0066 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 2014 Aug;92(8):661-8. doi: 10.1139/cjpp-2014-0066. Epub 
      2014 Jun 6.