PMID- 25008792
OWN - NLM
STAT- MEDLINE
DCOM- 20150526
LR  - 20220311
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 158
IP  - 1-3
DP  - 2014 Sep
TI  - Motivational deficits in individuals at-risk for psychosis and across the course 
      of schizophrenia.
PG  - 52-7
LID - S0920-9964(14)00316-8 [pii]
LID - 10.1016/j.schres.2014.06.024 [doi]
AB  - Motivational impairment is a critical factor that contributes to functional 
      disability in schizophrenia and undermines an individual's ability to engage in 
      and adhere to effective treatment. However, little is known about the 
      developmental trajectory of deficits in motivation and whether these deficits are 
      present prior to the onset of psychosis. We assessed several components of 
      motivation including anticipatory versus consummatory pleasure (using the 
      Temporal Experience of Pleasure Scale (TEPS)), and behavioral drive, behavioral 
      inhibition, and reward responsivity (using the Behavioral Inhibition 
      Scale/Behavioral Activation Scale (BIS/BAS)). A total of 234 participants 
      completed study measures, including 60 clinical high risk (CHR) participants, 60 
      recent-onset schizophrenia participants (RO), 78 chronic schizophrenia 
      participants (SZ) and 29 healthy controls (HC) age matched to the CHR group. CHR 
      participants endorsed greater deficits in anticipatory pleasure and reward 
      responsivity, relative to HC comparison participants and individuals diagnosed 
      with schizophrenia. Motivational deficits were not more pronounced over the 
      course of illness. Depressed mood was uniquely associated with impairments in 
      motivation in the CHR sample, but not the schizophrenia participants. The results 
      suggest that CHR individuals experience multiple contributors to impaired 
      motivation, and thus multiple leverage points for treatment.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Schlosser, Danielle A
AU  - Schlosser DA
AD  - University of California at San Francisco, San Francisco, CA, USA. Electronic 
      address: danielle.schlosser@ucsf.edu.
FAU - Fisher, Melissa
AU  - Fisher M
AD  - University of California at San Francisco, San Francisco, CA, USA; San Francisco 
      Department of Veterans Affairs Medical Center, San Francisco, CA, USA.
FAU - Gard, David
AU  - Gard D
AD  - San Francisco State University, San Francisco, CA, USA.
FAU - Fulford, Daniel
AU  - Fulford D
AD  - University of California at San Francisco, San Francisco, CA, USA; Palo Alto 
      Medical Foundation Research Institute, Palo Alto, CA, USA.
FAU - Loewy, Rachel L
AU  - Loewy RL
AD  - University of California at San Francisco, San Francisco, CA, USA.
FAU - Vinogradov, Sophia
AU  - Vinogradov S
AD  - University of California at San Francisco, San Francisco, CA, USA; San Francisco 
      Department of Veterans Affairs Medical Center, San Francisco, CA, USA.
LA  - eng
GR  - UL1 TR0000004/TR/NCATS NIH HHS/United States
GR  - K23 MH097795-01/MH/NIMH NIH HHS/United States
GR  - R34 MH100399/MH/NIMH NIH HHS/United States
GR  - T32 MH089920/MH/NIMH NIH HHS/United States
GR  - K23 MH097795/MH/NIMH NIH HHS/United States
GR  - UL1 TR000004/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140705
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anticipation, Psychological
MH  - Chronic Disease
MH  - Depression
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - *Motivation
MH  - Reward
MH  - Risk
MH  - *Schizophrenic Psychology
MH  - Young Adult
PMC - PMC4152418
MID - NIHMS609639
OTO - NOTNLM
OT  - Anticipatory Pleasure
OT  - Avolition
OT  - Duration of illness
OT  - Motivation
OT  - Psychosis
OT  - Reward
OT  - Schizophrenia
COIS- Conflict of Interest We wish to confirm that there are no known conflicts of 
      interest associated with this publication and there has been no significant 
      financial support for this work that could have influenced its outcome.
EDAT- 2014/07/11 06:00
MHDA- 2015/05/27 06:00
PMCR- 2015/09/01
CRDT- 2014/07/11 06:00
PHST- 2014/01/31 00:00 [received]
PHST- 2014/06/18 00:00 [revised]
PHST- 2014/06/19 00:00 [accepted]
PHST- 2014/07/11 06:00 [entrez]
PHST- 2014/07/11 06:00 [pubmed]
PHST- 2015/05/27 06:00 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - S0920-9964(14)00316-8 [pii]
AID - 10.1016/j.schres.2014.06.024 [doi]
PST - ppublish
SO  - Schizophr Res. 2014 Sep;158(1-3):52-7. doi: 10.1016/j.schres.2014.06.024. Epub 
      2014 Jul 5.