PMID- 25009603
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 8
IP  - 2
DP  - 2014 Aug
TI  - Emulsified isoflurane anesthesia decreases brain-derived neurotrophic factor 
      expression and induces cognitive dysfunction in adult rats.
PG  - 471-477
AB  - Post-operative cognitive dysfunction (POCD) is a severe complication 
      characterized by cognitive decline in patients following anesthesia and surgery. 
      Previous studies have suggested that volatile anesthetics, for example 
      isoflurane, may contribute to such impairment. In the present study, the effects 
      of emulsified isoflurane (EI) exposure on cognitive function, as well as the 
      potential mechanisms, were investigated in animal models. Eight-month-old male 
      rats were administered a single intravenous injection of 8% EI. The rats were 
      then subjected to the Morris water maze test to assess their cognitive functions 
      at different time-points following drug administration. Samples were taken in 
      order to detect the plasma corticosterone concentration and the levels of 
      hippocampal brain-derived neurotrophic factor (BDNF) and nerve growth factor 
      (NGF), as well as the expression of BDNF and NGF in the hippocampal region. The 
      results showed that a single injection of EI caused reversible learning and 
      memory dysfunction in adult rats. It was found that downregulation of BDNF 
      expression may contribute to the isoflurane-induced cognitive impairment of these 
      rats. Increased expression of NGF may be associated with the protection mechanism 
      subsequent to learning and memory function decline, and therefore may accelerate 
      the recovery of cognitive function.
FAU - Zhang, Fan
AU  - Zhang F
AD  - Department of Anesthesiology, Affiliated Hospital of Zunyi Medical College, 
      Zunyi, Guizhou 563000, P.R. China.
FAU - Zhu, Zhao-Qiong
AU  - Zhu ZQ
AD  - Department of Anesthesiology, Affiliated Hospital of Zunyi Medical College, 
      Zunyi, Guizhou 563000, P.R. China.
FAU - Liu, DE-Xing
AU  - Liu DX
AD  - Department of Anesthesiology, Affiliated Hospital of Zunyi Medical College, 
      Zunyi, Guizhou 563000, P.R. China.
FAU - Zhang, Chao
AU  - Zhang C
AD  - Department of Anesthesiology, Affiliated Hospital of Zunyi Medical College, 
      Zunyi, Guizhou 563000, P.R. China.
FAU - Gong, Qi-Hai
AU  - Gong QH
AD  - Department of Pharmacology, Zunyi Medical College, Zunyi, Guizhou 563000, P.R. 
      China.
FAU - Zhu, Yu-Hang
AU  - Zhu YH
AD  - Department of Anesthesiology, Affiliated Hospital of Zunyi Medical College, 
      Zunyi, Guizhou 563000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20140610
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC4079394
OTO - NOTNLM
OT  - brain-derived neutrophic factor
OT  - cognitive dysfunction
OT  - emulsified isoflurane
OT  - nerve growth factor
OT  - plasma corticosterone
EDAT- 2014/07/11 06:00
MHDA- 2014/07/11 06:01
PMCR- 2014/06/10
CRDT- 2014/07/11 06:00
PHST- 2013/12/22 00:00 [received]
PHST- 2014/05/27 00:00 [accepted]
PHST- 2014/07/11 06:00 [entrez]
PHST- 2014/07/11 06:00 [pubmed]
PHST- 2014/07/11 06:01 [medline]
PHST- 2014/06/10 00:00 [pmc-release]
AID - etm-08-02-0471 [pii]
AID - 10.3892/etm.2014.1769 [doi]
PST - ppublish
SO  - Exp Ther Med. 2014 Aug;8(2):471-477. doi: 10.3892/etm.2014.1769. Epub 2014 Jun 
      10.