PMID- 25009627
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 8
IP  - 2
DP  - 2014 Aug
TI  - Red cell distribution width predicts short- and long-term outcomes of acute 
      congestive heart failure more effectively than hemoglobin.
PG  - 600-606
AB  - The present study compared short- and long-term prognostic values of red blood 
      cell distribution width (RDW) with those of hemoglobin (Hgb) among patients with 
      acute congestive heart failure (CHF) in a cardiac care unit. The cross-sectional 
      study examined data from 521 patients with acute CHF who were admitted to a 
      cardiac care unit and followed up for 24 months (median). Mean Hgb levels in 
      patients who succumbed (DIH) or remained alive (AIH) were 11.0+/-1.8 and 11.8+/-2.6 
      g/l (P>0.05), respectively. Median values of RDW were 16.2% and 14.4%, 
      respectively (P<0.0001). During the 24-month follow-up, mean levels of Hgb in 
      groups with and without endpoints were 11.4+/-2.5 and 12.5+/-2.4 g/dl (P<0.0001), 
      respectively. Median RDW values were 14.9 and 13.8%, respectively (P<0.0001). 
      Logistic regression analysis showed that in-hospital mortality was significantly 
      associated with RDW (P=0.044), New York Heart Association (NYHA) functional class 
      IV (P=0.0037), estimated glomerular filtration rate (eGFR) (P=0.042) and 
      C-reactive protein (P=0.0044), but not with Hgb (P=0.10). The multivariate Cox 
      proportional hazard model selected RDW [hazard ratio (HR), 2.19; P<0.0001], left 
      ventricular ejection fraction (HR 0.81, P=0.0016), age (10-year increase; HR 
      1.19, P=0.0017) and NYHA functional classes III/IV (HR 1.52, P=0.0029) as 
      independent predictors of long-term outcomes after adjustment, but not Hgb (HR 
      1.01, P=0.86). Higher RDW values in acute CHF patients at admission were 
      associated with worse short- and long-term outcomes and RDW values were more 
      prognostically relevant than Hgb levels.
FAU - Dai, Yuxiang
AU  - Dai Y
AD  - Department of Cardiology, Juntendo University School of Medicine, Tokyo 113-8421, 
      Japan ; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan 
      University, Shanghai 200032, P.R. China.
FAU - Konishi, Hakuoh
AU  - Konishi H
AD  - Department of Cardiology, Juntendo University School of Medicine, Tokyo 113-8421, 
      Japan.
FAU - Takagi, Atsutoshi
AU  - Takagi A
AD  - Department of Cardiology, Juntendo University School of Medicine, Tokyo 113-8421, 
      Japan.
FAU - Miyauchi, Katsumi
AU  - Miyauchi K
AD  - Department of Cardiology, Juntendo University School of Medicine, Tokyo 113-8421, 
      Japan.
FAU - Daida, Hiroyuki
AU  - Daida H
AD  - Department of Cardiology, Juntendo University School of Medicine, Tokyo 113-8421, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20140604
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC4079416
OTO - NOTNLM
OT  - anemia
OT  - biomarker
OT  - heart failure
OT  - prognosis
OT  - red blood cell distribution width
EDAT- 2014/07/11 06:00
MHDA- 2014/07/11 06:01
PMCR- 2014/06/04
CRDT- 2014/07/11 06:00
PHST- 2013/12/01 00:00 [received]
PHST- 2014/03/27 00:00 [accepted]
PHST- 2014/07/11 06:00 [entrez]
PHST- 2014/07/11 06:00 [pubmed]
PHST- 2014/07/11 06:01 [medline]
PHST- 2014/06/04 00:00 [pmc-release]
AID - etm-08-02-0600 [pii]
AID - 10.3892/etm.2014.1755 [doi]
PST - ppublish
SO  - Exp Ther Med. 2014 Aug;8(2):600-606. doi: 10.3892/etm.2014.1755. Epub 2014 Jun 4.