PMID- 25009765
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140710
LR  - 20211021
IS  - 2160-8288 (Print)
IS  - 2160-8288 (Electronic)
IS  - 2160-8288 (Linking)
VI  - 4
DP  - 2014
TI  - REM Sleep Behavior and Motor Findings in Parkinson's Disease: A Cross-sectional 
      Analysis.
PG  - 245
LID - 10.7916/D84B2ZDF [doi]
LID - 245
AB  - BACKGROUND: Parkinson's disease (PD) represents a major public health challenge 
      that will only grow in our aging population. Understanding the connection between 
      PD and associated prodromal conditions, such as rapid eye movement sleep 
      behavioral disorder (RBD), is critical to identifying prevention strategies. 
      However, the relationship between RBD and severity of motor findings in early PD 
      is unknown. This study aims to examine this relationship. METHODS: The study 
      population consisted of 418 PD patients who completed the Movement Disorders 
      Society-United Parkinson's Disease Rating Scale (MDS-UPDRS) and rapid eye 
      movement sleep (REM) disorder questionnaires at the baseline visit of the Michael 
      J. Fox's Parkinson's Progression Markers Initiative (PPMI). Cross-sectional 
      analysis was carried out to assess the association between REM Sleep Behavior 
      Screening Questionnaire score and MDS UPDRS-3 (motor) score categories. 
      Correlation with a higher score category was described as "worse motor findings". 
      A score of 5 on the REM disorder questionnaire was defined as predictive of RBD. 
      RESULTS: Out of the 418 PD patients, 113 (27.0%) had RBD. With univariate 
      logistic regression analysis, individuals with scores predictive of RBD were 1.66 
      times more likely to have worse motor findings (p = 0.028). Even with age, 
      gender, and Geriatric Depression Scale scores taken into account, individuals 
      with scores predictive of RBD were 1.69 times more likely to have worse motor 
      findings (p = 0.025). DISCUSSION: PD patients with RBD symptoms had worse motor 
      findings than those unlikely to have RBD. This association provides further 
      evidence for the relationship between RBD and PD.
FAU - Mahajan, Abhimanyu
AU  - Mahajan A
AD  - Department of Neurology Johns Hopkins University, Baltimore, MD, USA.
FAU - Rosenthal, Liana S
AU  - Rosenthal LS
AD  - Department of Neurology Johns Hopkins University, Baltimore, MD, USA.
FAU - Gamaldo, Charlene
AU  - Gamaldo C
AD  - Department of Neurology Johns Hopkins University, Baltimore, MD, USA.
FAU - Salas, Rachel E
AU  - Salas RE
AD  - Department of Neurology Johns Hopkins University, Baltimore, MD, USA.
FAU - Pontone, Gregory M
AU  - Pontone GM
AD  - Department of Psychiatry and Behavioral Sciences Johns Hopkins University, 
      Baltimore, MD, USA.
FAU - McCoy, Arita
AU  - McCoy A
AD  - Department of Neurology Johns Hopkins University, Baltimore, MD, USA.
FAU - Umeh, Chizoba
AU  - Umeh C
AD  - Department of Neurology Johns Hopkins University, Baltimore, MD, USA.
FAU - Mari, Zoltan
AU  - Mari Z
AD  - Department of Neurology Johns Hopkins University, Baltimore, MD, USA.
LA  - eng
GR  - P50 NS038377/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20140623
PL  - England
TA  - Tremor Other Hyperkinet Mov (N Y)
JT  - Tremor and other hyperkinetic movements (New York, N.Y.)
JID - 101569493
PMC - PMC4070091
OTO - NOTNLM
OT  - Movement Disorders Society-United Parkinson's Disease Rating Scale
OT  - Parkinson's disease
OT  - motor findings
OT  - rapid eye movement sleep
COIS- Conflict of Interests: The authors report no conflict of interest. Disclaimer: 
      The views expressed in the submitted article by the authors are their own and not 
      an official position of the institution or funder.
EDAT- 2014/07/11 06:00
MHDA- 2014/07/11 06:01
PMCR- 2014/06/23
CRDT- 2014/07/11 06:00
PHST- 2014/04/16 00:00 [received]
PHST- 2014/05/20 00:00 [accepted]
PHST- 2014/07/11 06:00 [entrez]
PHST- 2014/07/11 06:00 [pubmed]
PHST- 2014/07/11 06:01 [medline]
PHST- 2014/06/23 00:00 [pmc-release]
AID - 10.7916/D84B2ZDF [doi]
PST - epublish
SO  - Tremor Other Hyperkinet Mov (N Y). 2014 Jun 23;4:245. doi: 10.7916/D84B2ZDF. 
      eCollection 2014.