PMID- 25010064
OWN - NLM
STAT- MEDLINE
DCOM- 20150120
LR  - 20181202
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 19
IP  - 4
DP  - 2014 Aug
TI  - Human leukocyte antigen epitope antigenicity and immunogenicity.
PG  - 428-35
LID - 10.1097/MOT.0000000000000100 [doi]
AB  - PURPOSE OF REVIEW: Human leukocyte antigen (HLA) antibodies are now recognized as 
      being specific for epitopes which can be defined structurally with amino acid 
      differences between HLA alleles. This article addresses two general perspectives 
      of HLA epitopes namely antigenicity, that is their reactivity with antibody and 
      immunogenicity, that is their ability of eliciting an antibody response. RECENT 
      FINDINGS: Single-antigen bead assays have shown that HLA antibodies recognize 
      epitopes that are equivalent to eplets or corresponding to eplets paired with 
      other residue configurations. There is now a website-based Registry of 
      Antibody-Defined HLA Epitopes (http://www.epregistry.com.br). Residue differences 
      within eplet-defined structural epitopes may also explain technique-dependent 
      variations in antibody reactivity determined in Ig-binding, C1q-binding and 
      lymphocytotoxicity assays.HLA antibody responses correlate with the numbers of 
      eplets on mismatched HLA antigens, and the recently proposed nonself-self 
      paradigm of epitope immunogenicity may explain the production of epitope-specific 
      antibodies. SUMMARY: These findings support the usefulness of HLA matching at the 
      epitope level, including the identification of acceptable mismatches for 
      sensitized patients and permissible mismatching for nonsensitized patients aimed 
      to reduce HLA antibody responses.
FAU - Duquesnoy, Rene J
AU  - Duquesnoy RJ
AD  - Division of Transplant Pathology, Thomas E. Starzl Transplantation Institute, 
      University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (Antibodies)
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Animals
MH  - Antibodies/*immunology
MH  - Antibody Formation/immunology
MH  - Antibody Specificity/immunology
MH  - Epitopes/chemistry/*immunology
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Testing
MH  - Humans
EDAT- 2014/07/11 06:00
MHDA- 2015/01/21 06:00
CRDT- 2014/07/11 06:00
PHST- 2014/07/11 06:00 [entrez]
PHST- 2014/07/11 06:00 [pubmed]
PHST- 2015/01/21 06:00 [medline]
AID - 00075200-201408000-00016 [pii]
AID - 10.1097/MOT.0000000000000100 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2014 Aug;19(4):428-35. doi: 
      10.1097/MOT.0000000000000100.