PMID- 25011017
OWN - NLM
STAT- MEDLINE
DCOM- 20150616
LR  - 20221207
IS  - 1439-4286 (Electronic)
IS  - 0018-5043 (Linking)
VI  - 46
IP  - 10
DP  - 2014 Sep
TI  - Relationship between serum levels of angiopoietin-related growth factor and 
      metabolic risk factors.
PG  - 685-90
LID - 10.1055/s-0034-1382078 [doi]
AB  - Angiopoietin-related growth factor (AGF, also known as angiopoietin-like protein 
      6) has been introduced as a novel hepatocyte-derived factor, which antagonizes 
      obesity and insulin resistance in mice. However, human studies show conflicting 
      results and are limited to a small cohort of patients. In the current study, we 
      therefore sought to investigate AGF serum levels in a large metabolically 
      well-characterized cohort. AGF serum concentrations were determined by commercial 
      enzyme-linked immunosorbent assay in 697 patients of a cohort from Eastern 
      Germany (Sorbs). Correlations of AGF serum levels with clinical and biochemical 
      measures of glucose and lipid metabolism, as well as markers of renal function, 
      were investigated. In nondiabetic subjects (n=627), AGF was positively correlated 
      with markers of insulin resistance and negatively correlated with high-density 
      lipoprotein cholesterol in univariate analyses (p<0.05). After adjustment for 
      age, gender, and body mass index, none of these factors remained independently 
      associated with AGF, neither in nondiabetic subjects nor in patients with type 2 
      diabetes mellitus (T2DM) (n=70). However, we confirmed existing data of 
      significantly higher AGF concentrations in patients with T2DM as compared to 
      controls in this large cohort. Circulating AGF is elevated in subjects with T2DM 
      and related to the type of antidiabetic treatment, but is not independently 
      associated with anthropometric parameters, indices of insulin sensitivity and 
      secretion, or a number of other adipokines.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Ebert, T
AU  - Ebert T
AD  - Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, 
      Germany.
FAU - Kralisch, S
AU  - Kralisch S
AD  - Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, 
      Germany.
FAU - Loessner, U
AU  - Loessner U
AD  - Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, 
      Germany.
FAU - Jessnitzer, B
AU  - Jessnitzer B
AD  - Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, 
      Germany.
FAU - Stumvoll, M
AU  - Stumvoll M
AD  - Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, 
      Germany.
FAU - Fasshauer, M
AU  - Fasshauer M
AD  - Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, 
      Germany.
FAU - Tonjes, A
AU  - Tonjes A
AD  - Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, 
      Germany.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140710
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (ANGPTL6 protein, human)
RN  - 0 (Angiopoietin-Like Protein 6)
RN  - 0 (Angiopoietin-like Proteins)
RN  - 0 (Angiopoietins)
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipoproteins, HDL)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Angiopoietin-Like Protein 6
MH  - Angiopoietin-like Proteins
MH  - Angiopoietins/*blood
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Cholesterol, HDL/metabolism
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Germany
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Lipoproteins, HDL/blood
MH  - Male
MH  - Mice
MH  - Middle Aged
EDAT- 2014/07/11 06:00
MHDA- 2015/06/17 06:00
CRDT- 2014/07/11 06:00
PHST- 2014/07/11 06:00 [entrez]
PHST- 2014/07/11 06:00 [pubmed]
PHST- 2015/06/17 06:00 [medline]
AID - 10.1055/s-0034-1382078 [doi]
PST - ppublish
SO  - Horm Metab Res. 2014 Sep;46(10):685-90. doi: 10.1055/s-0034-1382078. Epub 2014 
      Jul 10.