PMID- 25011106
OWN - NLM
STAT- MEDLINE
DCOM- 20150824
LR  - 20231213
IS  - 1934-6069 (Electronic)
IS  - 1931-3128 (Print)
IS  - 1931-3128 (Linking)
VI  - 16
IP  - 1
DP  - 2014 Jul 9
TI  - Measles virus suppresses RIG-I-like receptor activation in dendritic cells via 
      DC-SIGN-mediated inhibition of PP1 phosphatases.
PG  - 31-42
LID - S1931-3128(14)00224-8 [pii]
LID - 10.1016/j.chom.2014.06.008 [doi]
AB  - Dendritic cells (DCs) are targets of measles virus (MV) and play central roles in 
      viral dissemination. However, DCs express the RIG-I-like receptors (RLRs) RIG-I 
      and Mda5 that sense MV and induce type I interferon (IFN) production. Given the 
      potency of this antiviral response, RLRs are tightly regulated at various steps, 
      including dephosphorylation by PP1 phosphatases, which induces their activation. 
      We demonstrate that MV suppresses RIG-I and Mda5 by activating the C-type lectin 
      DC-SIGN and inducing signaling that prevents RLR dephosphorylation. MV binding to 
      DC-SIGN leads to activation of the kinase Raf-1, which induces the association of 
      PP1 inhibitor I-1 with GADD34-PP1 holoenzymes, thereby inhibiting phosphatase 
      activity. Consequently, GADD34-PP1 holoenzymes are unable to dephosphorylate 
      RIG-I and Mda5, hence suppressing type I IFN responses and enhancing MV 
      replication. Blocking DC-SIGN signaling allows RLR activation and suppresses MV 
      infection of DCs. Thus, MV subverts DC-SIGN to control RLR activation and escape 
      antiviral responses.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Mesman, Annelies W
AU  - Mesman AW
AD  - Department of Experimental Immunology, Academic Medical Center, University of 
      Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.
FAU - Zijlstra-Willems, Esther M
AU  - Zijlstra-Willems EM
AD  - Department of Experimental Immunology, Academic Medical Center, University of 
      Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.
FAU - Kaptein, Tanja M
AU  - Kaptein TM
AD  - Department of Experimental Immunology, Academic Medical Center, University of 
      Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.
FAU - de Swart, Rik L
AU  - de Swart RL
AD  - Department of Virology, Erasmus MC, 's-Gravendijkwal 230, 3015 CA Rotterdam, the 
      Netherlands.
FAU - Davis, Meredith E
AU  - Davis ME
AD  - Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 
      02115, USA.
FAU - Ludlow, Martin
AU  - Ludlow M
AD  - Department of Microbiology, Boston University, School of Medicine, Boston, MA 
      02118, USA.
FAU - Duprex, W Paul
AU  - Duprex WP
AD  - Department of Microbiology, Boston University, School of Medicine, Boston, MA 
      02118, USA.
FAU - Gack, Michaela U
AU  - Gack MU
AD  - Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 
      02115, USA.
FAU - Gringhuis, Sonja I
AU  - Gringhuis SI
AD  - Department of Experimental Immunology, Academic Medical Center, University of 
      Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands. Electronic 
      address: s.i.gringhuis@amc.uva.nl.
FAU - Geijtenbeek, Teunis B H
AU  - Geijtenbeek TB
AD  - Department of Experimental Immunology, Academic Medical Center, University of 
      Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands. Electronic 
      address: t.b.geijtenbeek@amc.uva.nl.
LA  - eng
GR  - R01 AI087846/AI/NIAID NIH HHS/United States
GR  - R01 AI099100/AI/NIAID NIH HHS/United States
GR  - R21 AI097699/AI/NIAID NIH HHS/United States
GR  - R01 AI105063/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Host Microbe
JT  - Cell host & microbe
JID - 101302316
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Immunologic)
RN  - EC 3.1.3.16 (Protein Phosphatase 1)
RN  - EC 3.6.1.- (RIGI protein, human)
RN  - EC 3.6.4.13 (DEAD Box Protein 58)
RN  - EC 3.6.4.13 (DEAD-box RNA Helicases)
SB  - IM
CIN - Cell Host Microbe. 2014 Jul 9;16(1):1-2. PMID: 25011100
MH  - Cell Adhesion Molecules/*metabolism
MH  - Cell Line
MH  - DEAD Box Protein 58
MH  - DEAD-box RNA Helicases/*metabolism
MH  - Dendritic Cells/*immunology/virology
MH  - *Host-Pathogen Interactions
MH  - Humans
MH  - Immune Evasion
MH  - Lectins, C-Type/*metabolism
MH  - Measles virus/*immunology/physiology
MH  - Protein Phosphatase 1/*antagonists & inhibitors
MH  - Receptors, Cell Surface/*metabolism
MH  - Receptors, Immunologic
PMC - PMC4159752
MID - NIHMS619653
EDAT- 2014/07/11 06:00
MHDA- 2015/08/25 06:00
PMCR- 2015/07/09
CRDT- 2014/07/11 06:00
PHST- 2014/01/15 00:00 [received]
PHST- 2014/04/02 00:00 [revised]
PHST- 2014/05/21 00:00 [accepted]
PHST- 2014/07/11 06:00 [entrez]
PHST- 2014/07/11 06:00 [pubmed]
PHST- 2015/08/25 06:00 [medline]
PHST- 2015/07/09 00:00 [pmc-release]
AID - S1931-3128(14)00224-8 [pii]
AID - 10.1016/j.chom.2014.06.008 [doi]
PST - ppublish
SO  - Cell Host Microbe. 2014 Jul 9;16(1):31-42. doi: 10.1016/j.chom.2014.06.008.