PMID- 25012095
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20211021
IS  - 1613-2246 (Electronic)
IS  - 0021-5155 (Linking)
VI  - 58
IP  - 5
DP  - 2014 Sep
TI  - Evaluation of corneal epithelial and stromal thickness in keratoconus using 
      spectral-domain optical coherence tomography.
PG  - 389-95
LID - 10.1007/s10384-014-0338-0 [doi]
AB  - PURPOSE: We sought to assess the corneal thickness of the epithelium and stroma 
      in keratoconic and normal eyes by spectral-domain optical coherence tomography 
      (SD-OCT). METHODS: Fifty-seven keratoconic and 20 normal eyes were studied. The 
      eyes were examined by SD-OCT, and the keratoconic eyes were subdivided into 2 
      groups: those showing only smooth corneal thinning and corneal protrusion on the 
      image (KC1 group) and those showing abnormalities in the Bowman layer or in the 
      stroma, or in both (KC2 group). The thicknesses at the corneal vertex and at the 
      superior, inferior, nasal, and temporal cornea 1.5 mm from the corneal vertex in 
      the KC1 group were compared with those in the normal group. The OCT findings in 
      the KC2 group were described. RESULTS: The epithelial thickness at the corneal 
      vertex and at the inferior and temporal cornea, and the stromal thickness at all 
      points were significantly thinner in the KC1 group than in the normal group 
      (p < 0.05). The epithelial and stromal thicknesses at the corneal vertex were 
      significantly correlated in the KC1 group and the normal group (r (2)  = 0.427, 
      p < 0.0001).The epithelial thickness in the KC2 group was not uniform owing to 
      Bowman layer scarring, stromal scars, and secondary corneal amyloidosis. 
      CONCLUSIONS: Although epithelial thinning is associated with stromal thinning, 
      when the cornea remains clear, the epithelial thickness may vary because of the 
      irregularity of the stroma beneath the epithelium in patients with keratoconus.
FAU - Maeda, Naoyuki
AU  - Maeda N
AD  - Department of Ophthalmology, Osaka University Graduate School of Medicine, Room 
      E7, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan, 
      nmaeda@ophthal.med.osaka-u.ac.jp.
FAU - Nakagawa, Tomoya
AU  - Nakagawa T
FAU - Higashiura, Ritsuko
AU  - Higashiura R
FAU - Fuchihata, Mutsumi
AU  - Fuchihata M
FAU - Koh, Shizuka
AU  - Koh S
FAU - Nishida, Kohji
AU  - Nishida K
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140712
PL  - Japan
TA  - Jpn J Ophthalmol
JT  - Japanese journal of ophthalmology
JID - 0044652
SB  - IM
MH  - Adult
MH  - Corneal Stroma/*pathology
MH  - Cross-Sectional Studies
MH  - Epithelium, Corneal/*pathology
MH  - Female
MH  - Humans
MH  - Keratoconus/*pathology
MH  - Male
MH  - Middle Aged
MH  - Tomography, Optical Coherence
MH  - Young Adult
EDAT- 2014/07/12 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/07/12 06:00
PHST- 2014/01/19 00:00 [received]
PHST- 2014/06/03 00:00 [accepted]
PHST- 2014/07/12 06:00 [entrez]
PHST- 2014/07/12 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - 10.1007/s10384-014-0338-0 [doi]
PST - ppublish
SO  - Jpn J Ophthalmol. 2014 Sep;58(5):389-95. doi: 10.1007/s10384-014-0338-0. Epub 
      2014 Jul 12.