PMID- 25012120
OWN - NLM
STAT- MEDLINE
DCOM- 20141111
LR  - 20140902
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 274
IP  - 1-2
DP  - 2014 Sep 15
TI  - Involvement of JAK/STAT signaling in the effect of cornel iridoid glycoside on 
      experimental autoimmune encephalomyelitis amelioration in rats.
PG  - 28-37
LID - S0165-5728(14)00193-3 [pii]
LID - 10.1016/j.jneuroim.2014.06.022 [doi]
AB  - In the present study, we investigated the therapeutic benefit of cornel iridoid 
      glycoside (CIG), the main component extracted from Cornus officinalis, in 
      experimental autoimmune encephalomyelitis (EAE) rats. CIG was intragastrically 
      administered daily after EAE initiation for 20days and reduced disease severity, 
      incidence, disease onset and ongoing paralysis. Histopathological staining showed 
      that CIG could reduce T cell entry to the central nervous system and microglia 
      activation, increased brain-derived neurotrophic factor (BDNF) expression and 
      mature oligodendrocytes, and decreased oligodendrocyte progenitor cells (OPCs). 
      Also, CIG treatment inhibited brain JAK/STAT1/3 and reduced proinflammatory 
      cytokines. CIG might be a novel potential therapeutic agent for multiple 
      sclerosis (MS).
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Yin, Linlin
AU  - Yin L
AD  - Department of Pharmacology, Xuan Wu Hospital of Capital Medical University, 
      Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative 
      Diseases of Ministry of Education, 45 Changchun Street, Beijing 100053, PR China. 
      Electronic address: yinll913@126.com.
FAU - Chen, Yongyan
AU  - Chen Y
AD  - School of Pharmaceutical Sciences, Zhengzhou University, 100 Science Avenue, 
      Zhengzhou, Henan Province 450001, PR China.
FAU - Qu, Zhao
AU  - Qu Z
AD  - Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, 12 
      Jichang Road, Guangzhou, Guangdong Province 510405, PR China.
FAU - Zhang, Li
AU  - Zhang L
AD  - Department of Pharmacology, Xuan Wu Hospital of Capital Medical University, 
      Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative 
      Diseases of Ministry of Education, 45 Changchun Street, Beijing 100053, PR China.
FAU - Wang, Qi
AU  - Wang Q
AD  - Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, 12 
      Jichang Road, Guangzhou, Guangdong Province 510405, PR China.
FAU - Zhang, Qi
AU  - Zhang Q
AD  - School of Pharmaceutical Sciences, Zhengzhou University, 100 Science Avenue, 
      Zhengzhou, Henan Province 450001, PR China.
FAU - Li, Lin
AU  - Li L
AD  - Department of Pharmacology, Xuan Wu Hospital of Capital Medical University, 
      Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative 
      Diseases of Ministry of Education, 45 Changchun Street, Beijing 100053, PR China. 
      Electronic address: linli97@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140628
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Iridoid Glucosides)
RN  - 0 (Jak3 protein, rat)
RN  - 0 (NF-kappa B)
RN  - 0 (STAT1 Transcription Factor)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (Stat1 protein, rat)
RN  - 0 (Stat3 protein, rat)
RN  - EC 2.7.10.2 (Jak1 protein, rat)
RN  - EC 2.7.10.2 (Janus Kinase 1)
RN  - EC 2.7.10.2 (Janus Kinase 3)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/immunology/metabolism
MH  - Disease Models, Animal
MH  - Encephalomyelitis, Autoimmune, Experimental/*drug therapy/*immunology/metabolism
MH  - Female
MH  - Iridoid Glucosides/*pharmacology
MH  - Janus Kinase 1/metabolism
MH  - Janus Kinase 3/metabolism
MH  - Multiple Sclerosis/drug therapy/immunology/metabolism
MH  - Myelin Sheath/drug effects/immunology
MH  - NF-kappa B/immunology/metabolism
MH  - Oligodendroglia/drug effects/immunology/metabolism
MH  - Rats
MH  - Rats, Inbred Lew
MH  - STAT1 Transcription Factor/metabolism
MH  - STAT3 Transcription Factor/metabolism
MH  - Signal Transduction/*drug effects/*immunology
MH  - Spinal Cord/drug effects/immunology/metabolism
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Cornel iridoid glycoside
OT  - Experimental autoimmune encephalomyelitis
OT  - JAK/STAT signaling
OT  - Multiple sclerosis
OT  - Neuroinflammation
EDAT- 2014/07/12 06:00
MHDA- 2014/11/12 06:00
CRDT- 2014/07/12 06:00
PHST- 2014/01/22 00:00 [received]
PHST- 2014/06/06 00:00 [revised]
PHST- 2014/06/17 00:00 [accepted]
PHST- 2014/07/12 06:00 [entrez]
PHST- 2014/07/12 06:00 [pubmed]
PHST- 2014/11/12 06:00 [medline]
AID - S0165-5728(14)00193-3 [pii]
AID - 10.1016/j.jneuroim.2014.06.022 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2014 Sep 15;274(1-2):28-37. doi: 10.1016/j.jneuroim.2014.06.022. 
      Epub 2014 Jun 28.