PMID- 25012431
OWN - NLM
STAT- MEDLINE
DCOM- 20141205
LR  - 20181202
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 166
DP  - 2014 Sep
TI  - Alterations in BDNF (brain derived neurotrophic factor) and GDNF (glial cell 
      line-derived neurotrophic factor) serum levels in bipolar disorder: The role of 
      lithium.
PG  - 193-200
LID - S0165-0327(14)00300-0 [pii]
LID - 10.1016/j.jad.2014.05.012 [doi]
AB  - OBJECTIVE: Brain-derived neurotrophic factor (BDNF) has been consistently 
      reported to be decreased in mania or depression in bipolar disorders. Evidence 
      suggests that Glial cell line-derived neurotrophic factor (GDNF) has a role in 
      the pathogenesis of mood disorders. Whether GDNF and BDNF act in the same way 
      across different episodes in bipolar disorders is unclear. METHOD: BDNF and GDNF 
      serum levels were measured simultaneously by enzyme-linked immunosorbent assay 
      (ELISA) method in 96 patients diagnosed with bipolar disorder according to DSM-IV 
      (37 euthymic, 33 manic, 26 depressed) in comparison to 61 healthy volunteers. 
      SCID- I and SCID-non patient version were used for clinical evaluation of the 
      patients and healthy volunteers respectively. Correlations between the two 
      trophic factor levels, and medication dose, duration and serum levels of lithium 
      or valproate were studied across different episodes of illness. RESULTS: Patients 
      had significantly lower BDNF levels during mania and depression compared to 
      euthymic patients and healthy controls. GDNF levels were not distinctive. However 
      GDNF/BDNF ratio was higher in manic state compared to euthymia and healthy 
      controls. Significant negative correlation was observed between BDNF and GDNF 
      levels in euthymic patients. While BDNF levels correlated positively, GDNF levels 
      correlated negatively with lithium levels. Regression analysis confirmed that 
      lithium levels predicted only GDNF levels positively in mania, and negatively in 
      euthymia. LIMITATIONS: Small sample size in different episodes and drug-free 
      patients was the limitation of thestudy. CONCLUSION: Current data suggests that 
      lithium exerts its therapeutic action by an inverse effect on BDNF and GDNF 
      levels, possibly by up-regulating BDNF and down-regulating GDNF to achieve 
      euthymia.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Tunca, Zeliha
AU  - Tunca Z
AD  - Dokuz Eylul University, Medical School, Izmir, Turkey. Electronic address: 
      zeliha.tunca@deu.edu.tr.
FAU - Ozerdem, Aysegul
AU  - Ozerdem A
AD  - Dokuz Eylul University, Medical School, Izmir, Turkey.
FAU - Ceylan, Deniz
AU  - Ceylan D
AD  - Dokuz Eylul University, Medical School, Izmir, Turkey.
FAU - Yalcin, Yaprak
AU  - Yalcin Y
AD  - Dokuz Eylul University, Medical School, Izmir, Turkey.
FAU - Can, Gunes
AU  - Can G
AD  - Dokuz Eylul University, Medical School, Izmir, Turkey.
FAU - Resmi, Halil
AU  - Resmi H
AD  - Dokuz Eylul University, Medical School, Izmir, Turkey.
FAU - Akan, Pinar
AU  - Akan P
AD  - Dokuz Eylul University, Medical School, Izmir, Turkey.
FAU - Ergor, Gul
AU  - Ergor G
AD  - Dokuz Eylul University, Medical School, Izmir, Turkey.
FAU - Aydemir, Omer
AU  - Aydemir O
AD  - Celal Bayar University, Faculty of Medicine, Manisa, Turkey.
FAU - Cengisiz, Cengiz
AU  - Cengisiz C
AD  - Celal Bayar University, Faculty of Medicine, Manisa, Turkey.
FAU - Kerim, Doyuran
AU  - Kerim D
AD  - Dokuz Eylul University, Medical School, Izmir, Turkey.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140522
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Antimanic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Lithium Compounds)
RN  - 614OI1Z5WI (Valproic Acid)
SB  - IM
MH  - Adult
MH  - Antimanic Agents/*administration & dosage/blood
MH  - Bipolar Disorder/*blood/diagnosis/drug therapy/*psychology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depression/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glial Cell Line-Derived Neurotrophic Factor/*blood
MH  - Humans
MH  - Lithium Compounds/*administration & dosage/blood
MH  - Male
MH  - Middle Aged
MH  - Valproic Acid/*administration & dosage/blood
OTO - NOTNLM
OT  - BDNF (Brain-derived neurotrophic factor)
OT  - Bipolar disorder
OT  - GDNF (glial cell line-derived neurotrophic factor)
OT  - Lithium
OT  - Valproate
EDAT- 2014/07/12 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/07/12 06:00
PHST- 2013/12/17 00:00 [received]
PHST- 2014/05/08 00:00 [revised]
PHST- 2014/05/09 00:00 [accepted]
PHST- 2014/07/12 06:00 [entrez]
PHST- 2014/07/12 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0165-0327(14)00300-0 [pii]
AID - 10.1016/j.jad.2014.05.012 [doi]
PST - ppublish
SO  - J Affect Disord. 2014 Sep;166:193-200. doi: 10.1016/j.jad.2014.05.012. Epub 2014 
      May 22.