PMID- 25013473
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 8
IP  - 2
DP  - 2014 Aug
TI  - Rapid onset lung squamous cell carcinoma with prominent peritoneal carcinomatosis 
      and an eosinophilic leukemoid reaction, with coexistence of the BRAF V600E and 
      oncogenic KRAS G12A mutations: A case report.
PG  - 589-593
AB  - Peritoneal carcinomatosis from lung cancer is rare, particularly from lung 
      squamous cell carcinoma (LSCC). Concurrent somatic BRAF and KRAS mutations within 
      the same tumor specimen have not been reported. The present study describes the 
      case of a treatment-naive LSCC patient with coexisting BRAF V600E and oncogenic 
      KRAS G12A mutations in the primary lung lesion and the peritoneal metastases. The 
      patient presented with prominent peritoneal carcinomatosis and an eosinophilic 
      leukemoid reaction, but no respiratory symptoms. The patient succumbed 8 days 
      after the onset of the condition due to rapid aggravation of the peritoneal 
      carcinomatosis. To the best of our knowledge, this is the first study concerning 
      the coexistence of BRAF and KRAS mutations in LSCC. Intensive activation of ERK 
      was also observed in the primary lung lesion and the peritoneal metastases. 
      Although the exact pathogenesis was unclear, the observations indicated that in 
      the present study, the BRAF V600E and KRAS G12A mutations may have cooperate in 
      inducing the malignant phenotype of LSCC. This case also highlighted the 
      potential aggressive course and unusual pattern of spread of this specific 
      dual-mutated tumor.
FAU - Li, Bin
AU  - Li B
AD  - Institute of Medical Sciences, Key Laboratory of Cancer Proteomics of Chinese 
      Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan 
      410008, P.R. China ; Division of Oncology, Xiangya Hospital, Central South 
      University, Changsha, Hunan 410008, P.R. China.
FAU - Lu, Jing Chen
AU  - Lu JC
AD  - Division of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 
      410008, P.R. China.
FAU - He, Dan
AU  - He D
AD  - Institute of Medical Sciences, Key Laboratory of Cancer Proteomics of Chinese 
      Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan 
      410008, P.R. China.
FAU - Wang, Jun
AU  - Wang J
AD  - Institute of Medical Sciences, Key Laboratory of Cancer Proteomics of Chinese 
      Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan 
      410008, P.R. China.
FAU - Zhou, Hui
AU  - Zhou H
AD  - Department of Radiology, Xiangya Hospital, Central South University, Changsha, 
      Hunan 410008, P.R. China.
FAU - Shen, Liangfang
AU  - Shen L
AD  - Division of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 
      410008, P.R. China.
FAU - Zhang, Chunfang
AU  - Zhang C
AD  - Institute of Medical Sciences, Key Laboratory of Cancer Proteomics of Chinese 
      Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan 
      410008, P.R. China.
FAU - Duan, Chaojun
AU  - Duan C
AD  - Institute of Medical Sciences, Key Laboratory of Cancer Proteomics of Chinese 
      Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan 
      410008, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20140522
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC4081353
OTO - NOTNLM
OT  - BRAF V600E mutation
OT  - KRAS G12A
OT  - coexistence
OT  - lung squamous cell
EDAT- 2014/07/12 06:00
MHDA- 2014/07/12 06:01
PMCR- 2014/05/22
CRDT- 2014/07/12 06:00
PHST- 2013/11/14 00:00 [received]
PHST- 2014/04/30 00:00 [accepted]
PHST- 2014/07/12 06:00 [entrez]
PHST- 2014/07/12 06:00 [pubmed]
PHST- 2014/07/12 06:01 [medline]
PHST- 2014/05/22 00:00 [pmc-release]
AID - ol-08-02-0589 [pii]
AID - 10.3892/ol.2014.2169 [doi]
PST - ppublish
SO  - Oncol Lett. 2014 Aug;8(2):589-593. doi: 10.3892/ol.2014.2169. Epub 2014 May 22.