PMID- 2501440
OWN - NLM
STAT- MEDLINE
DCOM- 19890818
LR  - 20190516
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 46
IP  - 2
DP  - 1989 Aug
TI  - Macrophage function in murine allogeneic bone marrow radiation chimeras in the 
      early phase after transplantation.
PG  - 134-43
AB  - We tested several of the functions of macrophages (M phi) in the early phase 
      after allogeneic bone marrow transfer to get information about this important 
      aspect of the nonspecific immune system in the T-cell-deficient recipient. On 
      days 3-5 after transfer, the number of M phi was reduced in the spleen, liver, 
      lungs, and peritoneal cavity (Pe). The phagocytosis of sheep red blood cells 
      (SRBC) by these M phi was normal or even enhanced, as in the case of Pe-M phi. 
      Already on days 8-12 after transfer, the number of M phi in spleen and liver 
      exceeded that of controls, whereas the number was still reduced in lungs and Pe. 
      We examined their ability to kill P815 tumor cells, to produce tumor necrosis 
      factor-alpha (TNF alpha), to phagocytose SRBC, to produce reactive oxygen 
      intermediates (ROI) in vitro and to kill Listeria monocytogenes in vivo. Most 
      functions were normal and often even enhanced, depending on the organ origin, but 
      the ability of Pe-M phi to produce ROI was reduced. Proliferative response to 
      macrophage colony-stimulating factor (M-CSF) and killing of YAC-1 tumor cells 
      revealed a high frequency of macrophage precursor cells in the spleen and liver 
      and a high natural killer (NK) activity in the liver. Altogether, enhanced 
      nonspecific immune function, especially preactivated M phi, may enable chimeras 
      to survive attacks by opportunistic pathogens.
FAU - Roesler, J
AU  - Roesler J
AD  - Department of Immunobiology, Fraunhofer-Institute for Toxicology and Aerosol 
      Research, Hannover, Federal Republic of Germany.
FAU - Baccarini, M
AU  - Baccarini M
FAU - Vogt, B
AU  - Vogt B
FAU - Lohmann-Matthes, M L
AU  - Lohmann-Matthes ML
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (Colony-Stimulating Factors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Bone Marrow/immunology
MH  - *Bone Marrow Transplantation
MH  - Cell Division/drug effects
MH  - Cell Line
MH  - Colony Count, Microbial
MH  - Colony-Stimulating Factors/pharmacology
MH  - Listeria monocytogenes
MH  - Liver/cytology/microbiology/physiology
MH  - Lung/cytology
MH  - Macrophages/immunology/*physiology/transplantation
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Oxygen/metabolism
MH  - Peritoneal Cavity/cytology/metabolism
MH  - Radiation Chimera
MH  - Spleen/cytology/microbiology/physiology
MH  - Transplantation, Homologous
MH  - Tumor Cells, Cultured/drug effects
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 1989/08/01 00:00
MHDA- 1989/08/01 00:01
CRDT- 1989/08/01 00:00
PHST- 1989/08/01 00:00 [pubmed]
PHST- 1989/08/01 00:01 [medline]
PHST- 1989/08/01 00:00 [entrez]
AID - 10.1002/jlb.46.2.134 [doi]
PST - ppublish
SO  - J Leukoc Biol. 1989 Aug;46(2):134-43. doi: 10.1002/jlb.46.2.134.