PMID- 25015148
OWN - NLM
STAT- MEDLINE
DCOM- 20150223
LR  - 20220408
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 1180
DP  - 2014
TI  - Characterization of HER2 status by fluorescence in situ hybridization (FISH) and 
      immunohistochemistry (IHC).
PG  - 181-207
LID - 10.1007/978-1-4939-1050-2_10 [doi]
AB  - The use of human epidermal growth factor receptor type 2 (HER2) gene 
      amplification and overexpression as a molecular predictive marker has become 
      critically important for proper selection of breast cancer patients for treatment 
      with targeted therapeutic agents such as trastuzumab, lapatinib, pertuzumab, and 
      T-DM1. A high level of sensitivity and specificity of molecular tests for this 
      alteration is desirable. The American Society of Clinical Oncology and College of 
      American Pathology have jointly established consensus guidelines to standardize 
      characterization of this alteration in breast cancers. This chapter provides a 
      brief overview of pre-analytic and analytical processing of breast specimens as 
      well as subsequent molecular evaluation for HER2 status.
FAU - Press, Oliver A
AU  - Press OA
AD  - Department of Pathology, USC Keck School of Medicine, Los Angeles, CA, USA.
FAU - Guzman, Roberta
AU  - Guzman R
FAU - Cervantes, Monica
AU  - Cervantes M
FAU - Santiago, Angela
AU  - Santiago A
FAU - Press, Michael F
AU  - Press MF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (Indicators and Reagents)
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Humans
MH  - Immunohistochemistry/*methods
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Indicators and Reagents
MH  - Microscopy, Fluorescence
MH  - Quality Control
MH  - Receptor, ErbB-2/*metabolism
MH  - Staining and Labeling
EDAT- 2014/07/13 06:00
MHDA- 2015/02/24 06:00
CRDT- 2014/07/13 06:00
PHST- 2014/07/13 06:00 [entrez]
PHST- 2014/07/13 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
AID - 10.1007/978-1-4939-1050-2_10 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2014;1180:181-207. doi: 10.1007/978-1-4939-1050-2_10.