PMID- 25015703
OWN - NLM
STAT- MEDLINE
DCOM- 20150715
LR  - 20211203
IS  - 1878-3627 (Electronic)
IS  - 0922-6028 (Linking)
VI  - 32
IP  - 5
DP  - 2014
TI  - Functional protection of learning and memory abilities in rats with vascular 
      dementia.
PG  - 689-700
LID - 10.3233/RNN-140409 [doi]
AB  - PURPOSE: The present study clarified the effects of repetitive transcranial 
      magnetic stimulation (rTMS) in rats with vascular dementia (VaD) and explored the 
      underlying mechanisms. METHODS: Two-vessel occlusion was used as a VaD model. Two 
      weeks after carotid artery occlusion, high (5 Hz) or low (1 Hz) frequency rTMS 
      were applied for 10 days. Spatial learning and memory abilities were tested with 
      a Morris water maze. Hippocampal CA1 neurons were histologically examined. The 
      expressions of mammalian target of rapamycin (mTOR) and eukaryotic initiation 
      factor 4E (eIF-4E) in CA1 were detected by western blot, and 
      immunohistochemistry. RESULTS: Unlike unlesioned control animals, VaD rats had an 
      impaired morphology of CA1 neurons and a reduced ability of spatial memory. rTMS 
      significantly improved both, the morphology and the learning and memory abilities 
      of VaD rats compared to untreated lesioned rats. Protein expressions of mTOR and 
      eIF-4E in CA1 of VaD rats were lower than in control rats but rTMS significantly 
      increased the expression compared to untreated VaD rats. CONCLUSIONS: rTMS 
      promotes recovery of learning and memory abilities of VaD rats. Molecular 
      analysis suggests that the beneficial effect of rTMS may be partly induced by 
      upregulation of protein expressions of mTOR and eIF-4E in CA1.
FAU - Yang, Huiyun
AU  - Yang H
AD  - School of Biomedical Engineering, Tianjin Medical University, Tianjin, China.
FAU - Shi, Ouyan
AU  - Shi O
AD  - School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
FAU - Jin, Yanjiao
AU  - Jin Y
AD  - General Hospital, Tianjin Medical University, Tianjin, China.
FAU - Henrich-Noack, Petra
AU  - Henrich-Noack P
AD  - Institute of Medical Psychology, Medical Faculty, Otto-von-Guericke University, 
      Magdeburg, Germany.
FAU - Qiao, Haixuan
AU  - Qiao H
AD  - School of Biomedical Engineering, Tianjin Medical University, Tianjin, China.
FAU - Cai, Chunquan
AU  - Cai C
AD  - Department of Neurosurgery, Tianjin Children's Hospital, Tianjin, China.
FAU - Tao, Huaying
AU  - Tao H
AD  - General Hospital, Tianjin Medical University, Tianjin, China.
FAU - Tian, Xin
AU  - Tian X
AD  - School of Biomedical Engineering, Tianjin Medical University, Tianjin, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Restor Neurol Neurosci
JT  - Restorative neurology and neuroscience
JID - 9005499
RN  - 0 (Eukaryotic Initiation Factor-4E)
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Biophysics
MH  - CA1 Region, Hippocampal/pathology
MH  - Dementia, Vascular/*complications/pathology
MH  - Disease Models, Animal
MH  - Eukaryotic Initiation Factor-4E/metabolism
MH  - Gene Expression Regulation/physiology/radiation effects
MH  - Learning Disabilities/*etiology/*therapy
MH  - Male
MH  - Maze Learning
MH  - Memory Disorders/*etiology/*therapy
MH  - Neurons/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - TOR Serine-Threonine Kinases/metabolism
MH  - Time Factors
MH  - Transcranial Magnetic Stimulation/*methods
OTO - NOTNLM
OT  - 2-vessel occlusion
OT  - Morris Water Maze
OT  - Vascular dementia (VaD)
OT  - eukaryotic translation initiation factor 4 (eIF-4E)
OT  - learning and memory
OT  - mammalian target of rapamycin (mTOR)
OT  - repetitive transcranial magnetic stimulation (rTMS)
EDAT- 2014/07/13 06:00
MHDA- 2015/07/16 06:00
CRDT- 2014/07/13 06:00
PHST- 2014/07/13 06:00 [entrez]
PHST- 2014/07/13 06:00 [pubmed]
PHST- 2015/07/16 06:00 [medline]
AID - K747776164P3T710 [pii]
AID - 10.3233/RNN-140409 [doi]
PST - ppublish
SO  - Restor Neurol Neurosci. 2014;32(5):689-700. doi: 10.3233/RNN-140409.