PMID- 25016542
OWN - NLM
STAT- MEDLINE
DCOM- 20150601
LR  - 20171003
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 122
DP  - 2014 Oct 1
TI  - The effect of dendrimer generations on the structure of Q(G) LLC mesophase and 
      drug release.
PG  - 30-37
LID - S0927-7765(14)00248-3 [pii]
LID - 10.1016/j.colsurfb.2014.05.013 [doi]
AB  - In this paper the cosolubilization of 2nd, 3rd, and 4th generations of 
      polypropyleneimine (PPI: PPI-G2, -G3, and -G4) dendrimers with sodium diclofenac 
      (Na-DFC) into reverse gyroid cubic (Q(G)) liquid crystals is reported. Structural 
      properties and interactions of PPI dendrimers with and without the drug were 
      studied using small-angle X-ray scattering, attenuated total reflected Fourier 
      transform infrared (ATR-FTIR) spectroscopy, and differential scanning calorimetry 
      (DSC) measurements. Incorporation of PPI-G2 (without Na-DFC) into Q(G) mesophase 
      led to a decrease of 78A in the lattice parameter. Solubilization of higher PPI 
      generations, G3 and G4, led to increases in the lattice parameter to 57A and 64A, 
      respectively. At 25wt%, each of the dendrimers caused a phase transition 
      Q(G)-->reverse hexagonal (HII). According to ATR-FTIR and DSC, the large lattice 
      parameter values of G3 and G4 (relative to G2) embedment were assigned to their 
      interactions with the carboxyl groups of GMO at the interface in comparison to 
      the strong interaction of PPI-G2 with the water. Cosolubilization of Na-DFC with 
      PPI-G2 revealed enlargement of the lattice parameter (of the new HII mesophase), 
      while in the case of G3 and G4 systems no significant influence was seen with 
      Na-DFC. The release of Na-DFC from Q(G) and HII systems was followed by UV-vis 
      spectroscopy and revealed generation-dependence on drug release. As dendrimer 
      generation increased, the cumulative drug release decreased.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Bitan-Cherbakovsky, Liron
AU  - Bitan-Cherbakovsky L
AD  - The Ratner Chair of Chemistry, Casali Institute of Applied Chemistry, The 
      Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra 
      Campus, Givat Ram, Jerusalem 91904, Israel.
FAU - Aserin, Abraham
AU  - Aserin A
AD  - The Ratner Chair of Chemistry, Casali Institute of Applied Chemistry, The 
      Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra 
      Campus, Givat Ram, Jerusalem 91904, Israel.
FAU - Garti, Nissim
AU  - Garti N
AD  - The Ratner Chair of Chemistry, Casali Institute of Applied Chemistry, The 
      Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra 
      Campus, Givat Ram, Jerusalem 91904, Israel. Electronic address: 
      garti@vms.huji.ac.il.
LA  - eng
PT  - Journal Article
DEP - 20140522
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Dendrimers)
RN  - 0 (Drug Carriers)
RN  - 144O8QL0L1 (Diclofenac)
SB  - IM
MH  - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage
MH  - Calorimetry, Differential Scanning
MH  - Dendrimers/*chemistry
MH  - Diclofenac/*administration & dosage
MH  - *Drug Carriers
MH  - Scattering, Small Angle
MH  - Spectrophotometry, Ultraviolet
MH  - Spectroscopy, Fourier Transform Infrared
MH  - X-Ray Diffraction
OTO - NOTNLM
OT  - Cubic mesophases
OT  - Hexagonal mesophases
OT  - Monoolein
OT  - Polypropylene imine
OT  - Sodium diclofenac
EDAT- 2014/07/14 06:00
MHDA- 2015/06/02 06:00
CRDT- 2014/07/14 06:00
PHST- 2013/09/02 00:00 [received]
PHST- 2014/04/09 00:00 [revised]
PHST- 2014/05/08 00:00 [accepted]
PHST- 2014/07/14 06:00 [entrez]
PHST- 2014/07/14 06:00 [pubmed]
PHST- 2015/06/02 06:00 [medline]
AID - S0927-7765(14)00248-3 [pii]
AID - 10.1016/j.colsurfb.2014.05.013 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2014 Oct 1;122:30-37. doi: 
      10.1016/j.colsurfb.2014.05.013. Epub 2014 May 22.